Roxin T, Sighetea E, Bujar H
Med Interne. 1978 Jul-Sep;16(3):285-9.
To improve the therapeutic methods in malignant lymphomas a new irradiation schedule is suggested i.e., ultrafractionated radiotherapy in small daily doses spaced out over a long period of time until the tumor dose of 3,500 R is reached. This treatment was used in 26 patients with malignant lymphomas--most of whom in stages III and IV--as well as in patients with recurrences that no longer responded to chemotherapy. Total remissions were obtained as well as an improvement of survival : 18 of the 16 patients are still in life and 8 of these have already been followed up for more than 5 years. The tumor dose per field did not exceed 2,000 R in the patients under concomitant chemotherapy. Ultrafractionated X-ray was very well tolerated by patients with altered general condition and even by those with recurrences or previous irradiation sequelae.
为改进恶性淋巴瘤的治疗方法，建议采用一种新的放疗方案，即超分割放疗，每日剂量小，在很长一段时间内分散进行，直至达到3500拉德的肿瘤剂量。该治疗方法应用于26例恶性淋巴瘤患者（其中大多数为Ⅲ期和Ⅳ期）以及对化疗不再有反应的复发患者。获得了完全缓解以及生存期的改善：16例患者中有18例仍存活，其中8例已随访超过5年。在接受同步化疗的患者中，每个照射野的肿瘤剂量不超过2000拉德。一般状况改变的患者，甚至复发或有既往放疗后遗症的患者，对超分割X线治疗的耐受性都非常好。
