Kamei Hiroyuki, Homma Yuki, Takeuchi Ippei, Hajitsu Genta, Tozawa Kaori, Hatano Masakazu, Fukui Aiko, Hanya Manako, Yamada Shigeki, Iwata Nakao
Office of Clinical Pharmacy Practice and Health Care Management, Faculty of Pharmacy, Meijo University, Nagoya, Aichi, Japan.
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Clin Psychopharmacol Neurosci. 2020 Feb 29;18(1):49-57. doi: 10.9758/cpn.2020.18.1.49.
To improve poor medication adherence in schizophrenic patients, long-acting injectable (LAI) antipsychotics are used. However, it has not yet become common in Japan. Recently, aripiprazole LAI was approved for alternative injection into the deltoid muscle in addition to the gluteal muscle. The acceptance for the proposal to switch from gluteal to deltoid injections of aripiprazole LAI was investigated.
The subjects were 32 outpatients with schizophrenia who had continuously received aripiprazole LAI administration into the gluteal muscle for ≥ 6 months. In the patients who had continued deltoid injection for 3 months after switching, the changes in the pain and shame in comparison with gluteal injections were evaluated.
Switching to the deltoid injection was chosen by 17 out of 32 patients. Three months later, 9 patients were still receiving deltoid injections with highly rated satisfaction. The main reasons for switching to deltoid injections included the pain and shame associated with gluteal injections. The main reason for returning to the gluteal injection was the pain experienced from the injection in the deltoid.
The option to select the injected area was based on the amount of pain in the deltoid and gluteal sites, leading to the widespread use of aripiprazole LAI.
为提高精神分裂症患者不佳的药物依从性，使用了长效注射用（LAI）抗精神病药物。然而，在日本其尚未普及。最近，阿立哌唑长效注射剂除了可注射入臀肌外，还被批准可选择注射入三角肌。本研究调查了从臀肌注射改为三角肌注射阿立哌唑长效注射剂这一建议的接受情况。
研究对象为32例门诊精神分裂症患者，这些患者连续接受阿立哌唑长效注射剂臀肌注射≥6个月。在改为三角肌注射并持续3个月的患者中，评估与臀肌注射相比疼痛和羞耻感的变化。
32例患者中有17例选择改为三角肌注射。3个月后，9例患者仍在接受三角肌注射，满意度较高。改为三角肌注射的主要原因包括与臀肌注射相关的疼痛和羞耻感。恢复为臀肌注射的主要原因是三角肌注射时的疼痛。
注射部位的选择基于三角肌和臀肌部位的疼痛程度，这使得阿立哌唑长效注射剂得到广泛使用。
