Möschl P, Keiler A, Lubec G, Mayr W R, Salem G, Szalay S, Glöckler M
Wien Klin Wochenschr. 1977 Jan 7;89(1):1-7.
Left side orthotopic homotransplantation of the lung was performed in 8 mongrel dogs pre-sensitized by full-thickness skin transplants. The degree of sensitization was assessed by control of the lymphocytotoxic antibody titre. The behaviour of haemolytic complement activity, as well as the alterations in antibody titre were recorded up to 60 minutes after opening of the anastomoses. Evaluation was performed by analyses of significance. A significant decrease in lymphocytotoxic antibody titre (p less than 0.001), as well as a significant diminution in complement activity (p less than 0.01) was observed in blood samples from the pulmonary vein of the graft during the first five minutes following recirculation. This resulted from an interaction of both systems in the immune reaction. The further complement consumption by the graft in contrast to the constancy of the lymphocytotoxic antibody titre in the subsequent post-transplantation period can be explained by antibody-independent complement activation. Vena cava-- pulmonary vein differences in the lymphocytotoxic antibody titre and complement activity are correlated only five minutes after opening of the anastomoses (r = 0.75), which confirms the independence of both systems during later course of the reaction.
对8只经全层皮肤移植预致敏的杂种犬进行了左侧肺原位同种移植。通过控制淋巴细胞毒性抗体滴度来评估致敏程度。在吻合口开放后60分钟内记录溶血补体活性的变化以及抗体滴度的改变。通过显著性分析进行评估。在再循环后的头五分钟内，从移植肺的肺静脉采集的血样中观察到淋巴细胞毒性抗体滴度显著降低（p<0.001），补体活性也显著降低（p<0.01）。这是免疫反应中两个系统相互作用的结果。与移植后随后时期淋巴细胞毒性抗体滴度的恒定相比，移植物进一步消耗补体可以用抗体非依赖性补体激活来解释。吻合口开放仅五分钟后，腔静脉与肺静脉在淋巴细胞毒性抗体滴度和补体活性方面的差异具有相关性（r = 0.75），这证实了在反应后期两个系统的独立性。
