Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, Jilin 130012, People's Republic of China.
Department of Chemistry, University of Utah, 315 South 1400 East, Room 2020, Salt Lake City, Utah 84112, United States.
Inorg Chem. 2020 Jun 1;59(11):7380-7388. doi: 10.1021/acs.inorgchem.9b02775. Epub 2020 Jan 21.
In this report, we describe the synthesis of two porphyrin-containing Pt(II) supramolecular assemblies via coordination-driven self-assembly. X-ray crystallographic analysis on one assembly reveals that the metalla-assembly formation imposes large interchromophore distances, leading to a higher O generation efficiency, relative to the corresponding small molecular precursors. The metalla-assemblies were examined as photosensitizers for photodynamic therapy as the potential reduction of the unfavorable self-aggregation phenomenon. In vivo and in vitro investigations demonstrate that the metalla-assemblies exhibit enhanced anticancer activity with minimal dose requirement and side effects comparable to the small molecule precursors. Thus, our work demonstrates that self-assembly provides a promising methodology for enhancing the therapeutic effectiveness of anticancer agents.
在本报告中，我们描述了通过配位驱动自组装合成的两种含卟啉的 Pt(II) 超分子组装体。对一个组装体的 X 射线晶体学分析表明，金属组装体的形成导致了较大的发色团间距离，从而相对于相应的小分子前体具有更高的 O 生成效率。这些金属组装体被用作光动力治疗的光敏剂，以潜在减少不利的自聚集现象。体内和体外研究表明，金属组装体在最小剂量要求下表现出增强的抗癌活性，且副作用与小分子前体相当。因此，我们的工作表明，自组装为增强抗癌药物的治疗效果提供了一种很有前途的方法。
