大样本葡萄膜炎眼中环扎膜形成与黄斑水肿发展的关系

Relationship of Epiretinal Membrane Formation and Macular Edema Development in a Large Cohort of Uveitic Eyes.

机构信息

USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.

出版信息

Ocul Immunol Inflamm. 2021 Jul 4;29(5):915-921. doi: 10.1080/09273948.2019.1704026. Epub 2020 Jan 21.

DOI:10.1080/09273948.2019.1704026

PMID:31961201

Abstract

: To identify the temporal relationship and clinical characteristics of epiretinal membrane (ERM) and macular edema (ME) formation in uveitic eyes.: A total of 269 subjects (444 uveitic eyes) met study inclusion criteria. Comprehensive ophthalmic examination, spectral domain-optical coherence tomography (SD-OCT), and clinical testing were carried out.: Of the 444 uveitic eyes, 229 eyes (51.6%) developed an ERM, whereas 87 eyes (19.1%) developed ME. The odds ratios (ORs) of systemic disease causing uveitis and resulting in ERM and ME were significantly higher in posterior uveitis (OR 6.56, 95% CI 2.98-14.46; < .0001) and panuveitis (OR 10.09, 95% CI 4.05-25.15; < .0001). Temporal analysis revealed that an ERM was noted concurrently or prior to ME development in 93.8% of eyes.: ERM and ME are primarily observed in posterior uveitis and panuveitis associated with systemic diseases. The temporal relationship highlights the importance of characterization of ERM as it relates to the development of uveitic ME.

摘要

目的

明确葡萄膜炎眼内视网膜前膜（ERM）和黄斑水肿（ME）形成的时间关系和临床特征。

方法

共纳入符合研究标准的 269 名患者（444 只患眼）。进行全面眼科检查、频域光相干断层扫描（SD-OCT）和临床检查。

结果

在 444 只患眼中，229 只（51.6%）患眼发生 ERM，87 只（19.1%）患眼发生 ME。引起葡萄膜炎的全身疾病导致 ERM 和 ME 的比值比（OR）在后葡萄膜炎（OR6.56，95%CI2.98-14.46； <.0001）和全葡萄膜炎（OR10.09，95%CI4.05-25.15； <.0001）中显著更高。时间分析显示，93.8%的患眼 ERM 与 ME 的发生同时或之前发生。