Nielsen G D, Kristiansen U, Hansen L, Alarie Y
Danish National Institute of Occupational Health, Hellerup.
Arch Toxicol. 1988;62(2-3):209-15. doi: 10.1007/BF00570142.
The immediate irritation response induced by mixtures of vapours of cumene (isopropyl benzene) and n-propanol was evaluated in mice according to the standard method (Designation: E 981-84) from The American Society for Testing and Materials. The animal model allows prediction of the irritation response in humans. Analyses of the results from the initial periods of the experiments leads to the hypothesis that competitive agonism exists between the two substances. Extrapolation of the results to TLV concentration levels taking into account the apparent dissociation constants leads further to expectation of additivity of the effects of mixtures of vapours. Following the initial response there is a fading or a desensitization stage. After desensitization, the responses were close to those of cumene alone. This may suggest that the receptor contains different binding sites which desensitize to a different extent.
根据美国材料与试验协会的标准方法（编号：E 981 - 84），对小鼠评估了异丙苯（枯烯）和正丙醇蒸汽混合物引起的即时刺激反应。该动物模型可预测人类的刺激反应。对实验初期结果的分析得出一种假设，即这两种物质之间存在竞争性激动作用。考虑到表观解离常数，将结果外推至阈限值浓度水平，进一步得出蒸汽混合物效应具有相加性的预期。在初始反应之后，存在一个消退或脱敏阶段。脱敏后，反应接近于单独使用异丙苯时的反应。这可能表明受体含有不同的结合位点，其脱敏程度不同。
