Nielsen G D, Bakbo J C, Holst E
Acta Pharmacol Toxicol (Copenh). 1984 Apr;54(4):292-8. doi: 10.1111/j.1600-0773.1984.tb01933.x.
The propene derivatives, allyl acetate, allyl alcohol, allyl ether, and acrolein were investigated for their property as sensory irritant in Ssc:CF-1 mice. The concentration of the chemicals necessary to depress the respiratory rate by 50% ( RD50 ) due to sensory irritation of the upper respiratory tract were 2.9, 3.9, 5.0 and 2.9 p.p.m., respectively. The potency of these propene derivatives varied very little for their concentration in air, in p.p.m., to depress the respiratory rate by 50%. However, when the potency is expressed in terms of thermodynamic activity acrolein was found to be 10 times more potent than the other propene derivates. This may be explained either by a higher reactivity of the carbon-carbon double bond or the involvement of the aldehyde group in a secondary chemical binding. No secondary chemical binding can be invoked for allyl acetate, allyl alcohol or allyl ether. In general, the chemical structure CH2 = CH-CH-O may be suspected to allow a molecule to act as a strong sensory irritant. The TLV's were predicted from the relation: TLV approximately equal to 0.03 X RD50 and were found to be 0.1, 0.1, 0.15, and 0.1 for allyl acetate, allyl alcohol, allyl ether, and acrolein, respectively. No pulmonary irritation was found at the concentration causing a 50% decrease in respiratory rate.
对丙烯衍生物醋酸烯丙酯、烯丙醇、烯丙基醚和丙烯醛作为Ssc:CF - 1小鼠的感觉刺激物的特性进行了研究。由于上呼吸道感觉刺激导致呼吸频率降低50%（RD50）所需的化学物质浓度分别为2.9、3.9、5.0和2.9 ppm。这些丙烯衍生物在空气中以ppm计的降低呼吸频率50%的浓度效力变化很小。然而，当以热力学活性表示效力时，发现丙烯醛的效力比其他丙烯衍生物高10倍。这可能是由于碳 - 碳双键的更高反应性或醛基参与二级化学结合来解释。对于醋酸烯丙酯、烯丙醇或烯丙基醚，无法调用二级化学结合。一般来说，化学结构CH2 = CH - CH - O可能被怀疑使分子能够作为强烈的感觉刺激物起作用。根据TLV约等于0.03×RD50的关系预测了阈限值，发现醋酸烯丙酯、烯丙醇、烯丙基醚和丙烯醛的阈限值分别为0.1、0.1、0.15和0.1。在导致呼吸频率降低50%的浓度下未发现肺部刺激。
