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氯化锶对培养骨中前列腺素E2诱导的骨吸收的影响。

Effect of strontium chloride on bone resorption induced by prostaglandin E2 in cultured bone.

作者信息

Matsumoto A

机构信息

Department of Dental Pharmacology, School of Dentistry, Hokkaido University, Sapporo, Japan.

出版信息

Arch Toxicol. 1988;62(2-3):240-1. doi: 10.1007/BF00570150.

DOI:10.1007/BF00570150
PMID:3196163
Abstract

We examined whether the bone resorption induced by PGE2 was inhibited by SrCl2 using 45Ca-labelled calvaria of CD-strain mice in tissue culture. It was found that Sr salts inhibited physiological bone resorption in a dose-dependent manner (0.1-5.0 mM) and did not act via PGE2. Accordingly, it was suggested that Sr salts did not inhibit bone resorption induced by exogenous PGE2.

摘要

我们使用组织培养中的CD品系小鼠的45Ca标记颅骨，研究了SrCl2是否能抑制PGE2诱导的骨吸收。结果发现，Sr盐以剂量依赖性方式（0.1 - 5.0 mM）抑制生理性骨吸收，且并非通过PGE2起作用。因此，提示Sr盐不能抑制外源性PGE2诱导的骨吸收。

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本文引用的文献

1
Strontium "rickets": bone, calcium and strontium changes.锶“佝偻病”：骨骼、钙和锶的变化
Australas Ann Med. 1961 Aug;10:213-22. doi: 10.1111/imj.1961.10.3.213.
2
Effects of a bone resorptive factor from human cancer ascites fluid on rat bone cell calcium and cyclic AMP.
Calcif Tissue Int. 1980;30(3):191-7. doi: 10.1007/BF02408627.
3
Perfusion of the isolated parathyroid gland of the goat and sheep.山羊和绵羊离体甲状旁腺的灌注
Nature. 1966 Jan 1;209(5018):55-7. doi: 10.1038/209055a0.
甲状旁腺素(1-84)或雷奈酸锶对绝经后原发性骨质疏松症妇女骨形成标志物的影响：一项随机、开放标签临床试验的结果。
Osteoporos Int. 2011 Sep;22(9):2529-37. doi: 10.1007/s00198-010-1460-6. Epub 2010 Oct 30.
4
Characteristics of calcium uptake by calcitonin-treated mouse calvaria in vitro.降钙素处理的小鼠颅骨体外钙摄取的特征
Calcif Tissue Res. 1974;15(2):85-92. doi: 10.1007/BF02059047.
5
Proceedings: Stimulation of calcitonin secretion by strontium.
J Physiol. 1974 Apr;238(1):76P-78P.
6
The relative influence of calcium, strontium and magnesium on calcitonin secretion in the pig.钙、锶和镁对猪降钙素分泌的相对影响。
Endocrinology. 1974 Apr;94(4):1176-80. doi: 10.1210/endo-94-4-1176.
7
Evidence that the bone resorption-stimulating factor produced by mouse fibrosarcoma cells is prostaglandin E 2 . A new model for the hypercalcemia of cancer.小鼠纤维肉瘤细胞产生的骨吸收刺激因子为前列腺素E2的证据。癌症高钙血症的一种新模型。
J Exp Med. 1972 Dec 1;136(6):1329-43. doi: 10.1084/jem.136.6.1329.
8
Strontium induced rickets: metabolic basis.锶诱导的佝偻病：代谢基础
Science. 1971 Nov 26;174(4012):949-51. doi: 10.1126/science.174.4012.949.
9
Bone resorption in vitro and in vivo in PGE-treated mice.PGE 处理的小鼠体内和体外的骨吸收
Proc Soc Exp Biol Med. 1977 Nov;156(2):373-7. doi: 10.3181/00379727-156-39939.
10
Bone cells: a serum-free medium supports proliferation in primary culture.骨细胞：一种无血清培养基可支持原代培养中的细胞增殖。
Science. 1978 Feb 3;199(4328):542-4. doi: 10.1126/science.564080.