Koch-Weser M, Garron D C, Gilley D W, Bergen D, Bleck T P, Morrell F, Ristanovic R, Whisler W W
Department of Psychology, Rush-Presbyterian-St Luke's Medical Center, Chicago, Ill.
Arch Neurol. 1988 Dec;45(12):1308-11. doi: 10.1001/archneur.1988.00520360026006.
To investigate whether surgical treatment of refractory epilepsy is associated with increased risk for serious psychopathology, 25 treated patients were compared with 25 current candidates for surgery matched on demographic and neuroepileptic characteristics. Diagnoses were made by the National Institute of Mental Health Diagnostic Interview Schedule. No differences between groups in lifetime or point prevalence rates were significant. The rate of psychosis in the postoperative group (8%) approximated the lower estimates in previous studies. Thus, surgical treatment of seizures did not increase the risk for psychopathology. However, patients with temporal lobe electroencephalogram foci or tumor as the epileptogenic lesion were more likely to have serious disorders than other patients. Also, anxiety disorders were more prevalent in our patient groups than in the general population.
为研究难治性癫痫的手术治疗是否与严重精神病理学风险增加相关，将25例接受手术治疗的患者与25例在人口统计学和神经癫痫特征方面相匹配的当前手术候选者进行了比较。诊断由美国国立精神卫生研究所诊断访谈表做出。两组在终生患病率或时点患病率方面无显著差异。术后组的精神病发病率（8%）接近先前研究中的较低估计值。因此，癫痫发作的手术治疗并未增加精神病理学风险。然而，以颞叶脑电图病灶或肿瘤作为致痫病变的患者比其他患者更易出现严重疾病。此外，焦虑症在我们的患者群体中比在普通人群中更普遍。
