三肽水凝胶中封端基团的选择会影响肿瘤球体三维细胞培养中的细胞活力。
Choice of Capping Group in Tripeptide Hydrogels Influences Viability in the Three-Dimensional Cell Culture of Tumor Spheroids.
作者信息
Wojciechowski Jonathan P, Martin Adam D, Mason Alexander F, Fife Christopher M, Sagnella Sharon M, Kavallaris Maria, Thordarson Pall
机构信息
School of Chemistry, The University of New South Wales, Sydney, NSW, 2052, Australia.
The Australian Centre for Nanomedicine and the, ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of New South Wales, Sydney, NSW, 2052, Australia.
出版信息
Chempluschem. 2017 Mar;82(3):383-389. doi: 10.1002/cplu.201600464. Epub 2016 Dec 7.
Two peptide-derived low-molecular-weight gelators bearing different capping groups, 9-fluorenylmethyloxycarbonyl (Fmoc) and phenothiazine, were synthesized and their gel networks were characterized. The variation of the N-terminal capping group affects the viability of these hydrogels as a three-dimensional cell culture for multicellular tumor spheroids. These results indicate that the phenothiazine capping group is a more biocompatible alternative to the widely used Fmoc moiety.
合成了两种带有不同封端基团（9-芴甲氧羰基（Fmoc）和吩噻嗪）的肽衍生低分子量凝胶剂，并对其凝胶网络进行了表征。N端封端基团的变化影响了这些水凝胶作为多细胞肿瘤球体三维细胞培养的可行性。这些结果表明，吩噻嗪封端基团是广泛使用的Fmoc部分更具生物相容性的替代物。
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