Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Science, Tel-Aviv University, Tel-Aviv 69978, Israel.
Langmuir. 2012 Jan 31;28(4):2015-22. doi: 10.1021/la204426q. Epub 2012 Jan 12.
Biocompatible hydrogels are of high interest as a class of biomaterials for tissue engineering, regenerative medicine, and controlled drug delivery. These materials offer three-dimensional scaffolds to support the growth of cells and development of hierarchical tissue structures. Fmoc-peptides were previously demonstrated as attractive building blocks for biocompatible hydrogels. Here, we further investigate the biophysical properties of Fmoc-peptide-based hydrogels for medical applications. We describe the structural and thermal properties of these Fmoc-peptides, as well as their self-assembly process. Additionally, we study the role of interactions between aromatic moieties in the self-assembly process and on the physical and structural properties of the hydrogels.
水凝胶作为组织工程、再生医学和控制药物释放的一类生物材料，具有很高的研究价值。这些材料为细胞的生长和层次组织结构的发育提供了三维支架。Fmoc-肽此前被证明是生物相容性水凝胶的有吸引力的构建块。在这里，我们进一步研究了 Fmoc-肽基水凝胶在医学中的应用的生物物理性质。我们描述了这些 Fmoc-肽的结构和热性质，以及它们的自组装过程。此外，我们研究了芳香族部分之间的相互作用在自组装过程以及水凝胶的物理和结构性质中的作用。
