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[食物的精神活性作用:一例急性肉豆蔻中毒病例]

[The Psychoactive Power of Foods: A Case of Acute Nutmeg Intoxication].

作者信息

Duarte Desidério, Mendonça Marta, Ramos Luís

机构信息

Departamento de Psiquiatria e Saúde Mental. Centro Hospitalar Universitário do Algarve. Faro. Portugal.

Medicina Geral e Familiar. Unidade de Saúde Familiar Ria Formosa. Faro. Portugal.

出版信息

Acta Med Port. 2019 Sep 30. doi: 10.20344/amp.12541.

Abstract

Ingestion of high doses of nutmeg causes potentially serious and disabling medical and psychiatric consequences. No isolated component of nutmeg has been identified as responsible for all symptoms observed during intoxication, however myristicin, one of the essential oil's components of this spice, is believed to be responsible for most psychoactive effects, although the exact mechanism is not known. Other constituents, such as elemicin, may also be involved. Symptoms of intoxication begin three to six hours after ingestion, resolve within the first 48 hours, and usually leave no sequelae. In this paper we present the case of a patient who after consuming 18 to 28 g of nutmeg developed a severe psychotic episode, with disorganized speech, psychomotor agitation and mystical/grandiose delusional ideation. The symptoms resolved quickly, and after one year of clinical stability without therapy, was discharged from the specialist consultation.

摘要

摄入高剂量肉豆蔻会导致潜在的严重且使人丧失能力的医学和精神后果。肉豆蔻的任何单一成分都未被确定为中毒期间观察到的所有症状的原因,然而,肉豆蔻醚,这种香料精油成分之一,被认为对大多数精神活性作用负责,尽管确切机制尚不清楚。其他成分,如榄香素,也可能参与其中。中毒症状在摄入后三到六小时开始,在最初48小时内消退,通常不会留下后遗症。在本文中,我们介绍了一名患者的病例,该患者在食用18至28克肉豆蔻后出现了严重的精神病发作,伴有言语紊乱、精神运动性激越和神秘/夸大的妄想观念。症状迅速消退,在未经治疗临床稳定一年后,从专科会诊中出院。

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