Department of Cell Biology, Faculty of Sciences, University of Geneva, 1211-4 Geneva, Switzerland.
Curr Biol. 2020 Jan 20;30(2):R83-R86. doi: 10.1016/j.cub.2019.11.060.
Two recent studies report that ZO proteins, the main scaffolding proteins of tight junctions, undergo liquid phase separation. This new concept provides understanding at the mechanistic level of how tight junctions are formed and how they participate in mechanochemical signaling in early development.
最近两项研究报告称,紧密连接的主要支架蛋白 ZO 蛋白会发生液相分离。这一新概念为紧密连接的形成方式以及它们如何参与早期发育中的机械化学信号传递提供了机制水平上的理解。