Beijing Key Laboratory of Emerging Organic Contaminants Control, State Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China.
Beijing Key Laboratory of Emerging Organic Contaminants Control, State Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China; State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment, South China Institute of Environmental Sciences, Ministry of Ecological Environment, Guangzhou 510655, China.
Environ Int. 2020 Mar;136:105480. doi: 10.1016/j.envint.2020.105480. Epub 2020 Jan 18.
The biological impacts of microplastics on many organisms have been well documented. However, the combined effects of microplastics and chiral chemicals on the aquatic food chain are less clear. In the present study, the enantioselective environmental behaviors of methamphetamine co-exposed with microplastics through an aquatic food chain (from Chlorella pyrenoidosa to Cipangopaludian cathayensis) have been investigated in a laboratory environment. It was found that the acute toxicity of methamphetamine against these two species was significantly increased in the presence of microplastics: Chlorella pyrenoidosa showed an EC shift from 0.77 to 0.32 mg L, while cipangopaludian cathayensis showed an LC shift from 4.15 to 1.48 mg L, upon the addition of microplastics as a co-contaminant with methamphetamine. Upon exposure to methamphetamine and microplastics, the oxidative damage of algae (19.9 to 36.8 nmol mgprot), apoptosis (increase about 2.17 times) and filtration rate (41.2 to 65.4 mL h) of snails were observably higher when compared to exposure to methamphetamine alone. After ingestion and accumulation of microplastics, the enantioselectivity, BCFs, BMFs, and distribution of methamphetamine were significantly altered. These results provide evidence that the co-occurrence of microplastics and the chiral drug methamphetamine may increase the burden on aquatic species, with potential further impacts throughout aquatic food chain.
微塑料对许多生物的生物影响已得到充分证实。然而，微塑料和手性化学品对水生食物链的综合影响还不太清楚。在本研究中，通过实验室环境研究了手性药物与微塑料在水生食物链（从蛋白核小球藻到中华圆田螺）中共暴露时的对映体环境行为。结果发现，微塑料的存在显著增加了手性药物对这两种生物的急性毒性：蛋白核小球藻的 EC 值从 0.77 增加到 0.32mg/L，中华圆田螺的 LC 值从 4.15 增加到 1.48mg/L。当微塑料与手性药物共存时，藻类的氧化损伤（19.9 至 36.8 nmol mgprot）、凋亡（增加约 2.17 倍）和过滤率（41.2 至 65.4 mL h）明显高于单独暴露于手性药物。在摄入和积累微塑料后，手性药物的对映选择性、BCFs、BMFs 和分布明显发生了变化。这些结果表明，微塑料和手性药物甲卡西酮的共同存在可能会增加水生生物的负担，对整个水生食物链可能会产生进一步的影响。
