Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, Shenzhen Second People's Hospital, Shenzhen University School of Medicine, First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.
Ophthalmic Res. 2020;63(3):224-233. doi: 10.1159/000503972. Epub 2020 Jan 21.
Controversial results regarding the associations between aldose reductase (AR) genetic polymorphisms and diabetic retinopathy (DR) have been reported for many years. The present meta-analysis was performed to clarify the effects of the AR gene C(-106)T polymorphism on DR risk. The PubMed, Web of Sciences, Cochrane library, EMBASE, Chinese National Knowledge Infrastructure, and Wan Fang databases were extensively searched in Chinese to select relevant studies with an updated date of April 25, 2018. The Newcastle-Ottawa Scale (NOS) was applied to assess quality. The random-effects model was applied to calculate the pooled OR and 95% CI. This meta-analysis identified 23 studies with an average score of 7.52 for NOS analysis, including 4,313 DR cases and 5,128 diabetes mellitus (DM) control cases. In the overall analysis, a significant association between the AR gene C(-106)T polymorphism and DR susceptibility was found. In subgroups stratified by DM type and ethnicity, significantly increased risks for DR were found in DM type 1, East Asian populations, and Middle Eastern populations. Compared with DR control cases, the following associations were found: T vs. C: OR 0.91, 95% CI 0.85-0.97, I2 = 72.9%; CT + TT vs. CC: OR 0.75, 95% CI 0.68-0.81, I2 = 86.7%; and CT vs. CC: OR 0.86, 95% CI 0.78-0.94, I2 = 70.5%. The results of this meta-analysis showed a significant association between the AR gene C(-106)T polymorphism and susceptibility to DR in DM patients. DM patients with allele T and CT+TT genotype of the AR gene may have a lower risk of DR.
多年来，醛糖还原酶（AR）基因遗传多态性与糖尿病视网膜病变（DR）之间的关联存在争议结果。本荟萃分析旨在阐明 AR 基因 C（-106）T 多态性对 DR 风险的影响。中文方面，广泛检索了 PubMed、Web of Sciences、Cochrane 图书馆、EMBASE、中国国家知识基础设施和万方数据库，以选择截至 2018 年 4 月 25 日的相关研究。应用纽卡斯尔-渥太华量表（NOS）评估质量。应用随机效应模型计算合并的 OR 和 95%CI。本荟萃分析共纳入 23 项研究，NOS 分析平均得分为 7.52，包括 4313 例 DR 病例和 5128 例糖尿病（DM）对照组病例。总体分析显示，AR 基因 C（-106）T 多态性与 DR 易感性之间存在显著关联。按 DM 类型和种族分层的亚组分析显示，1 型 DM、东亚人群和中东人群发生 DR 的风险显著增加。与 DR 对照组相比，发现以下关联：T 对 C：OR 0.91，95%CI 0.85-0.97，I2 = 72.9%；CT + TT 对 CC：OR 0.75，95%CI 0.68-0.81，I2 = 86.7%；CT 对 CC：OR 0.86，95%CI 0.78-0.94，I2 = 70.5%。本荟萃分析结果表明，AR 基因 C（-106）T 多态性与 DM 患者 DR 易感性之间存在显著关联。携带 AR 基因等位基因 T 和 CT+TT 基因型的 DM 患者发生 DR 的风险可能较低。
