Li Keng-Yuan, Tsai Cheng-Chia, Lin Tzu-Chieh, Wang Yin-Lin, Lin Feng-Huei, Lin Chun-Pin
Institute of Biomedical Engineering, National Taiwan University, No.49, Fanglan Rd., Da'an Dist., Taipei 10672, Taiwan.
Department of Neurosurgery, Mackay Memorial Hospital, No.92, Sec. 2, Zhongshan N. Rd., Zhongshan Dist., Taipei 10449, Taiwan.
Polymers (Basel). 2020 Jan 16;12(1):223. doi: 10.3390/polym12010223.
Dental caries (tooth decay) is the most frequent oral disease in humans. Filling cavities with a dental restorative material is the most common treatment, and glass ionomer cements are the main fluoride ion release restorative materials. The goal of this study was to develop a restorative compound with superior fluoride ion release and recharge abilities. Previously developed fluorinated bentolite and hydrophobized 3YSZ were used as two different inorganic fillers mixed in a bisphenol A-glycidyl methacrylate (Bis-GMA) matrix. XRD, FTIR, and TGA were used to determine the hydrophobic modification of these two inorganic fillers. In mechanical tests, including diameter tensile strength, flexural strength, and wear resistance, the developed composite resin was significantly superior to the commercial control. A WST-1 assay was used to confirm that the material displayed good biocompatibility. Furthermore, the simulation of the oral environment confirmed that the composite resin had good fluoride ion release and reloading abilities. Thus, the composite resin developed in this study may reduce secondary caries and provide a new choice for future clinical treatments.
龋齿（蛀牙）是人类最常见的口腔疾病。用牙科修复材料填充龋洞是最常见的治疗方法，而玻璃离子水门汀是主要的氟离子释放修复材料。本研究的目的是开发一种具有卓越氟离子释放和再充注能力的修复性化合物。先前开发的氟化膨润土和疏水化的3YSZ用作两种不同的无机填料，混合于双酚A-甲基丙烯酸缩水甘油酯（Bis-GMA）基质中。采用X射线衍射（XRD）、傅里叶变换红外光谱（FTIR）和热重分析（TGA）来测定这两种无机填料的疏水改性情况。在包括直径拉伸强度、弯曲强度和耐磨性的力学测试中，所开发的复合树脂明显优于市售对照品。采用WST-1检测法来确认该材料具有良好的生物相容性。此外，口腔环境模拟证实该复合树脂具有良好的氟离子释放和再充注能力。因此，本研究中开发的复合树脂可能会减少继发龋，并为未来的临床治疗提供新的选择。
