Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
Weight and Wellness Center, Tufts Medical Center, Boston, MA 02111, USA.
Nutrients. 2020 Jan 16;12(1):237. doi: 10.3390/nu12010237.
Both obesity and aging are associated with dysregulated immune and inflammatory responses. There is limited knowledge, however, on differences in the immune system between young and older adults with obesity. The goal of this study was to compare circulating inflammatory cytokines and T cell-mediated immune response between young and older women with obesity. Twenty-three young (23-43 years) and 21 older (60-83 years) women with obesity were recruited at the Weight and Wellness Center at Tufts Medical Center. Circulating inflammatory cytokines (CRP, IL-6, and IL-1β) and ex vivo indicators of T cell-mediated immune function were compared between the groups. Older women with obesity had significantly fewer circulating CD3+, CD8+, CD19+, and natural killer T (NKT) cells compared to young women with obesity ( = 0.016, < 0.0001, = 0.0003, and < 0.0001, respectively). However, with few exceptions, there was no significant difference in inflammation markers or stimulated lymphocyte proliferation and cytokine production by peripheral blood mononuclear cells between young and older participants. These findings are in contrast to those previously reported in young and old subjects with healthy weight and call for further investigation into the impact of obesity on premature aging of the immune system.
肥胖和衰老都与免疫和炎症反应失调有关。然而，关于肥胖的年轻人和老年人之间免疫系统的差异，我们的了解有限。本研究的目的是比较肥胖的年轻和老年女性之间循环炎症细胞因子和 T 细胞介导的免疫反应。在塔夫茨医疗中心的体重与健康中心招募了 23 名年轻（23-43 岁）和 21 名老年（60-83 岁）肥胖女性。比较了两组之间循环炎症细胞因子（CRP、IL-6 和 IL-1β）和体外 T 细胞介导的免疫功能指标。与年轻的肥胖女性相比，老年肥胖女性的循环 CD3+、CD8+、CD19+和自然杀伤 T（NKT）细胞明显减少（=0.016，<0.0001，=0.0003，<0.0001，分别）。然而，除了少数例外，年轻和老年参与者之间的炎症标志物或外周血单核细胞刺激的淋巴细胞增殖和细胞因子产生没有显著差异。这些发现与以前在体重健康的年轻和老年人群中报告的结果相反，需要进一步研究肥胖对免疫系统过早衰老的影响。
