Shanzer A, Libman J, Lazar R, Tor Y, Emery T
Department of Organic Chemistry, Weizmann Institute of Science, Rehovot, Israel.
Biochem Biophys Res Commun. 1988 Nov 30;157(1):389-94. doi: 10.1016/s0006-291x(88)80059-7.
Two families of trihydroxamic acid analogues of ferrichrome were chemically synthesized and tested for biological activity with Arthrobacter flavescens. Compounds using a tertiary amine as anchor showed little activity. Several compounds using tetrahedral carbon as anchor showed activity approaching or equalling that of the natural siderophore, ferrichrome. The biological activity is discussed in relation to physical and chemical properties of the analogues.
化学合成了两类高铁色素的三异羟肟酸类似物，并对其进行了与黄色节杆菌相关的生物活性测试。使用叔胺作为锚定基团的化合物几乎没有活性。几种使用四面体碳作为锚定基团的化合物显示出接近或等同于天然铁载体高铁色素的活性。结合类似物的物理和化学性质对生物活性进行了讨论。
