Emery T, Emery L, Olsen R K
Biochem Biophys Res Commun. 1984 Mar 30;119(3):1191-7. doi: 10.1016/0006-291x(84)90902-1.
A new synthetic analogue of ferrichrome, retrohydroxamate ferrichrome, has been examined for biological activity. Although spectroscopic evidence indicates that the analogue is a weaker Fe(III) chelator than ferrichrome, retrohydroxamate ferrichrome is indistinguishable from ferrichrome in its growth factor activity for Arthrobacter flavescens, and in its potency in antagonizing the antibiotic activity of albomyhcin against Bacillus subtilis. It is as active as ferrichrome as a siderophore for the fungus, Ustaligo sphaerogena. In contrast, desmethylretrohydroxamate ferrichrome shows no significant biological activity.
一种新的铁载体铬铁素合成类似物——逆羟肟酸型铬铁素，已对其生物活性进行了研究。尽管光谱证据表明该类似物作为Fe(III)螯合剂的能力比铬铁素弱，但逆羟肟酸型铬铁素在对黄色节杆菌的生长因子活性以及拮抗白霉素对枯草芽孢杆菌的抗生素活性方面，与铬铁素并无差异。作为球黑粉菌的铁载体，它与铬铁素的活性相当。相比之下，去甲基逆羟肟酸型铬铁素未表现出显著的生物活性。
