Lambertsen Kate L, Soares Catarina B, Gaist David, Nielsen Helle H
Department of Neurology, Odense University Hospital, J.B. Winsloewsvej 4, 5000 Odense C, Denmark.
Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsloewsvej 21, st, 5000 Odense C, Denmark.
Brain Sci. 2020 Jan 18;10(1):56. doi: 10.3390/brainsci10010056.
Neurofilaments (NFs) are quickly becoming the biomarkers of choice in the field of neurology, suggesting their use as an unspecific screening marker, much like the use of elevated plasma C-reactive protein (CRP) in other fields. With sensitive techniques being readily available, evidence is growing regarding the diagnostic and prognostic value of NFs in many neurological disorders. Here, we review the latest literature on the structure and function of NFs and report the strengths and pitfalls of NFs as markers of neurodegeneration in the context of neurological diseases of the central and peripheral nervous systems.
神经丝（NFs）正迅速成为神经病学领域的首选生物标志物，这表明它们可作为一种非特异性筛查标志物，类似于其他领域中使用的血浆C反应蛋白（CRP）升高的情况。随着敏感技术的 readily available，关于NFs在许多神经系统疾病中的诊断和预后价值的证据越来越多。在此，我们综述了关于NFs结构和功能的最新文献，并报告了在中枢和周围神经系统的神经疾病背景下，NFs作为神经退行性变标志物的优势和缺陷。
