Luepker R V, Caralis D G, Voigt G C, Burns R F, Murphy L W, Warbasse J R
Am J Cardiol. 1977 Feb;39(2):146-52. doi: 10.1016/s0002-9149(77)80183-5.
To evaluate methods for detecting pulmonary edema, pulmonary extravascular water volume was measured at 24 hour intervals (total 72 hours) in 25 patients with acute myocardial infarction. Measured lung water was compared with results of clinical, blood gas, X-ray and hemodynamic methods for detecting pulmonary edema. Increased pulmonary extravascular water volume on one or more measurements was observed in 18 of the 25 patients and was associated with an abnormal chest radiograph and increased pulmonary arterial wedge, pulmonary arterial diastolic and right atrial pressures. It was associated less well with clinical, blood gas and other hemodynamic measurements. Pulmonary arterial diastolic or pulmonary wedge pressure was a significant predictor of lung water 24 hours later. Both "preclinical pulmonary edema" and the "therapeutic phase lag" could be predicted from the pulmonary wedge pressure. Clinical, blood gas, radiographic and other hemodynamic measurements were not predictive.
为评估检测肺水肿的方法，对25例急性心肌梗死患者每隔24小时（共72小时）测量肺血管外水量。将测得的肺水量与检测肺水肿的临床、血气、X线和血流动力学方法的结果进行比较。25例患者中有18例在一次或多次测量中出现肺血管外水量增加，且与胸部X线片异常及肺动脉楔压、肺动脉舒张压和右心房压力升高有关。其与临床、血气和其他血流动力学测量的相关性较差。肺动脉舒张压或肺动脉楔压是24小时后肺水量的重要预测指标。“临床前期肺水肿”和“治疗阶段滞后”均可通过肺动脉楔压预测。临床、血气、影像学和其他血流动力学测量均无预测价值。
