Osterlind A, Engholm G, Jensen O M
Danish Cancer Registry, Institute of Cancer Epidemiology, Copenhagen, Denmark.
APMIS. 1988 Nov;96(11):953-63. doi: 10.1111/j.1699-0463.1988.tb00968.x.
Time trends in the incidence of cutaneous malignant melanoma were examined by analysing data from the Danish Cancer Registry, 1943-1982, by sex and subsite for 3509 male and 5305 female cases. The age-standardized incidence rate for cutaneous malignant melanoma for men and women in Denmark increased by five- to six-fold between 1943 and 1982. The increase varied by site; a particularly pronounced elevation was seen for tumours of the trunk in both men and women and of the leg in women. A statistical analysis of the effects of age, time and cohort showed steep increases in risk for progressively younger birth cohorts. This association was particular pronounced for sites other than the face, scalp and neck; for the latter sites, there was a much smaller increase for younger cohorts.
通过分析丹麦癌症登记处1943年至1982年的数据，按性别和发病部位对3509例男性和5305例女性皮肤恶性黑色素瘤病例进行了研究，以探讨其发病时间趋势。1943年至1982年间，丹麦男性和女性皮肤恶性黑色素瘤的年龄标准化发病率增长了五至六倍。发病率的增长因发病部位而异；男性和女性躯干以及女性腿部的肿瘤发病率有特别明显的升高。对年龄、时间和队列效应的统计分析表明，出生队列越年轻，风险增加越显著。这种关联在面部、头皮和颈部以外的部位尤为明显；对于后几个部位，年轻队列的发病率增长要小得多。
