Division of Prevention Science, University of California, San Francisco, CA, USA.
Bridge HIV San Francisco Department of Public Health, San Francisco, CA, USA.
J Gen Intern Med. 2020 Apr;35(4):1285-1288. doi: 10.1007/s11606-020-05651-2. Epub 2020 Jan 21.
Based on the results of the IPERGAY study, on-demand HIV pre-exposure prophylaxis (PrEP; also known as "non-daily PrEP," "event-driven PrEP," or "2-1-1 PrEP") is being requested more frequently by patients who have intermittent sexual risk or are unable/unwilling to take daily PrEP; therefore, clinicians will be increasingly required to familiarize themselves with its appropriate use. In this perspective, we summarize data related to on-demand PrEP, describe advantages and disadvantages for this alternative dosing strategy, and provide clinical counseling points.
基于 IPERGAY 研究的结果，按需 HIV 暴露前预防（PrEP；也称为“非每日 PrEP”、“事件驱动 PrEP”或“2-1-1 PrEP”）越来越多地被那些有间歇性性风险或无法/不愿意服用每日 PrEP 的患者所要求；因此，临床医生将越来越需要熟悉其正确使用方法。在这一观点中，我们总结了与按需 PrEP 相关的数据，描述了这种替代给药策略的优缺点，并提供了临床咨询要点。
