按需口服替诺福韦/恩曲他滨预防：每位临床医生都需要了解的知识。
On-Demand Oral Pre-exposure Prophylaxis with Tenofovir/Emtricitabine: What Every Clinician Needs to Know.
机构信息
Division of Prevention Science, University of California, San Francisco, CA, USA.
Bridge HIV San Francisco Department of Public Health, San Francisco, CA, USA.
出版信息
J Gen Intern Med. 2020 Apr;35(4):1285-1288. doi: 10.1007/s11606-020-05651-2. Epub 2020 Jan 21.
Abstract
Based on the results of the IPERGAY study, on-demand HIV pre-exposure prophylaxis (PrEP; also known as "non-daily PrEP," "event-driven PrEP," or "2-1-1 PrEP") is being requested more frequently by patients who have intermittent sexual risk or are unable/unwilling to take daily PrEP; therefore, clinicians will be increasingly required to familiarize themselves with its appropriate use. In this perspective, we summarize data related to on-demand PrEP, describe advantages and disadvantages for this alternative dosing strategy, and provide clinical counseling points.
摘要
基于 IPERGAY 研究的结果，按需 HIV 暴露前预防（PrEP；也称为“非每日 PrEP”、“事件驱动 PrEP”或“2-1-1 PrEP”）越来越多地被那些有间歇性性风险或无法/不愿意服用每日 PrEP 的患者所要求；因此，临床医生将越来越需要熟悉其正确使用方法。在这一观点中，我们总结了与按需 PrEP 相关的数据，描述了这种替代给药策略的优缺点，并提供了临床咨询要点。
相似文献
1
On-Demand Oral Pre-exposure Prophylaxis with Tenofovir/Emtricitabine: What Every Clinician Needs to Know.按需口服替诺福韦/恩曲他滨预防：每位临床医生都需要了解的知识。
J Gen Intern Med. 2020 Apr;35(4):1285-1288. doi: 10.1007/s11606-020-05651-2. Epub 2020 Jan 21.
2
On-demand pre-exposure prophylaxis with tenofovir disoproxil fumarate plus emtricitabine among men who have sex with men with less frequent sexual intercourse: a post-hoc analysis of the ANRS IPERGAY trial.按需服用富马酸替诺福韦二吡呋酯和恩曲他滨的男男性行为者中，性行为频率较低者的事前预防：ANRS IPERGAY 试验的事后分析。
Lancet HIV. 2020 Feb;7(2):e113-e120. doi: 10.1016/S2352-3018(19)30341-8. Epub 2019 Nov 26.
3
Daily and on-demand HIV pre-exposure prophylaxis with emtricitabine and tenofovir disoproxil (ANRS PREVENIR): a prospective observational cohort study.每日按需服用恩曲他滨和替诺福韦地索普西（ANRS PREVENIR）进行艾滋病毒暴露前预防：一项前瞻性观察队列研究。
Lancet HIV. 2022 Aug;9(8):e554-e562. doi: 10.1016/S2352-3018(22)00133-3. Epub 2022 Jun 27.
4
Efficacy, safety, and effect on sexual behaviour of on-demand pre-exposure prophylaxis for HIV in men who have sex with men: an observational cohort study.按需暴露前预防治疗用于男男性行为人群的有效性、安全性和对性行为影响的观察性队列研究。
Lancet HIV. 2017 Sep;4(9):e402-e410. doi: 10.1016/S2352-3018(17)30089-9. Epub 2017 Jul 23.
5
Daily or on-demand oral tenofovir disoproxil fumarate/emtricitabine for HIV pre-exposure prophylaxis: experience from a hospital-based clinic in France.每日或按需口服替诺福韦地索普西酯/恩曲他滨用于 HIV 暴露前预防：来自法国一家医院诊所的经验。
AIDS. 2018 Sep 24;32(15):2161-2169. doi: 10.1097/QAD.0000000000001939.
6
Pre-exposure Prophylaxis Use by Breastfeeding HIV-Uninfected Women: A Prospective Short-Term Study of Antiretroviral Excretion in Breast Milk and Infant Absorption.母乳喂养的未感染艾滋病毒妇女的暴露前预防用药：母乳中抗逆转录病毒药物排泄及婴儿吸收情况的前瞻性短期研究
PLoS Med. 2016 Sep 27;13(9):e1002132. doi: 10.1371/journal.pmed.1002132. eCollection 2016 Sep.
7
Uptake of PrEP and condom and sexual risk behavior among MSM during the ANRS IPERGAY trial.在法国国家艾滋病研究机构（ANRS）的IPERGAY试验中，男男性行为者（MSM）对暴露前预防（PrEP）的接受情况、避孕套使用情况及性风险行为
AIDS Care. 2016;28 Suppl 1(sup1):48-55. doi: 10.1080/09540121.2016.1146653. Epub 2016 Feb 17.
8
First year of pre-exposure prophylaxis implementation in France with daily or on-demand tenofovir disoproxil fumarate/emtricitabine.法国实施暴露前预防措施的第一年：每日或按需服用替诺福韦二吡呋酯/恩曲他滨。
J Antimicrob Chemother. 2019 Sep 1;74(9):2752-2758. doi: 10.1093/jac/dkz220.
9
Failure of pre-exposure prophylaxis with daily tenofovir/emtricitabine and the scenario of delayed HIV seroconversion.每日使用替诺福韦/恩曲他滨进行暴露前预防失败和延迟 HIV 血清转化的情况。
Int J Infect Dis. 2020 May;94:41-43. doi: 10.1016/j.ijid.2020.03.014. Epub 2020 Mar 13.
10
Single-dose pharmacokinetics and pharmacodynamics of oral tenofovir and emtricitabine in blood, saliva and rectal tissue: a sub-study of the ANRS IPERGAY trial.口服替诺福韦和恩曲他滨在血液、唾液及直肠组织中的单剂量药代动力学和药效学：ANRS IPERGAY试验的一项子研究
J Antimicrob Chemother. 2017 Feb;72(2):478-485. doi: 10.1093/jac/dkw412. Epub 2016 Sep 28.
引用本文的文献
1
National Trends in HIV Pre-Exposure Prophylaxis Dispensing to Young Adults, 2016-2023.2016 - 2023年向年轻人发放艾滋病病毒暴露前预防药物的全国趋势
J Gen Intern Med. 2025 May 9. doi: 10.1007/s11606-025-09574-8.
2
Susceptibility to Lenacapavir Among Newly Diagnosed HIV-Positive Patients Followed Up in Mozambique That Presented With Primary Antiretroviral Resistance to Other Classes.在莫桑比克接受随访的新诊断出的HIV阳性患者中，对其他类别药物存在原发性抗逆转录病毒耐药性的患者对来那卡韦的敏感性。
J Med Virol. 2025 Mar;97(3):e70317. doi: 10.1002/jmv.70317.
3
The Disparities of PrEP Adherence Among Men Who Have Sex With Men Between the Global South and the Global North: An Updated Determinantal Global Meta-Analysis.全球南方与全球北方男男性行为者中暴露前预防依从性的差异：一项最新的决定性全球荟萃分析。
J Acquir Immune Defic Syndr. 2025 May 1;99(1):1-8. doi: 10.1097/QAI.0000000000003635.
4
Evaluation of Hippocampal Microanatomy and Neuro-Biomarkers Following Administration of Silver Nanoparticles Conjugated with Tenofovir Disoproxil Fumarate in Experimental Diabetic Rats.富马酸替诺福韦二吡呋酯共轭银纳米颗粒给药后实验性糖尿病大鼠海马微观解剖学及神经生物标志物的评估
Pharmaceuticals (Basel). 2024 Dec 5;17(12):1635. doi: 10.3390/ph17121635.
5
Dynamicity of HIV Pre-exposure Prophylaxis Usage Pattern and Association with Executed Adherence in MSM: An Implementation Study in Hong Kong.男男性行为者中HIV暴露前预防用药模式的动态变化及其与实际依从性的关联：香港的一项实施研究
AIDS Behav. 2024 Apr;28(4):1327-1344. doi: 10.1007/s10461-023-04167-0. Epub 2023 Sep 29.
6
Pre-exposure prophylaxis service among men who have sex with men in Malaysia: findings from a discrete choice experiment.马来西亚男男性行为者中的暴露前预防服务：一项离散选择实验的结果。
Sci Rep. 2023 Aug 30;13(1):14200. doi: 10.1038/s41598-023-41264-5.
7
Delayed presentation of HIV among older individuals: a growing problem.老年人中 HIV 的延迟出现：一个日益严重的问题。
Lancet HIV. 2022 Apr;9(4):e269-e280. doi: 10.1016/S2352-3018(22)00003-0. Epub 2022 Feb 23.
8
Changes in Utilization of Birth Control and PrEP During COVID-19 in the USA: A Mixed-Method Analysis.美国 COVID-19 期间避孕和 PrEP 利用的变化：混合方法分析。
Arch Sex Behav. 2022 Jan;51(1):365-381. doi: 10.1007/s10508-021-02086-6. Epub 2021 Nov 8.
9
Facilitators and barriers of 2-1-1 HIV pre-exposure prophylaxis.2-1-1 HIV 暴露前预防的促进因素和障碍。
PLoS One. 2021 May 20;16(5):e0251917. doi: 10.1371/journal.pone.0251917. eCollection 2021.
10
PrEP Willingness and Adherence Self-Efficacy Among Men Who have Sex with Men with Recent Condomless Anal Sex in Urban China.中国城市中最近发生过无保护肛交性行为的男男性行为者对接受 PrEP 的意愿和坚持的自我效能感。
AIDS Behav. 2021 Nov;25(11):3482-3493. doi: 10.1007/s10461-021-03274-0. Epub 2021 May 1.
本文引用的文献
1
Motives for choosing, switching and stopping daily or event-driven pre-exposure prophylaxis - a qualitative analysis.选择、转换和停止每日或事件驱动的暴露前预防用药的动机 - 定性分析。
J Int AIDS Soc. 2019 Oct;22(10):e25389. doi: 10.1002/jia2.25389.
2
Changes in HIV Preexposure Prophylaxis Awareness and Use Among Men Who Have Sex with Men - 20 Urban Areas, 2014 and 2017.男男性行为者中 HIV 暴露前预防意识和使用情况的变化 - 2014 年和 2017 年 20 个城市地区。
MMWR Morb Mortal Wkly Rep. 2019 Jul 12;68(27):597-603. doi: 10.15585/mmwr.mm6827a1.
3
Drug-drug interactions between feminizing hormone therapy and pre-exposure prophylaxis among transgender women: the iFACT study.激素治疗与暴露前预防药物相互作用在跨性别女性中的研究：iFACT 研究。
J Int AIDS Soc. 2019 Jul;22(7):e25338. doi: 10.1002/jia2.25338.
4
Pleasure and PrEP: Pleasure-Seeking Plays a Role in Prevention Choices and Could Lead to PrEP Initiation.性愉悦与 PrEP：性愉悦在预防措施选择中扮演角色，并可能导致 PrEP 的启动。
Am J Mens Health. 2019 Jan-Feb;13(1):1557988319827396. doi: 10.1177/1557988319827396.
5
The Impact of Pre-Exposure Prophylaxis (PrEP) Use on Sexual Anxiety, Satisfaction, and Esteem Among Gay and Bisexual Men.暴露前预防（PrEP）使用对男同性恋和双性恋男性的性焦虑、满意度和自尊的影响。
J Sex Res. 2019 Nov-Dec;56(9):1128-1135. doi: 10.1080/00224499.2019.1572064. Epub 2019 Feb 19.
6
HIV Preexposure Prophylaxis, by Race and Ethnicity - United States, 2014-2016.HIV 暴露前预防，按种族和族裔划分-美国，2014-2016 年。
MMWR Morb Mortal Wkly Rep. 2018 Oct 19;67(41):1147-1150. doi: 10.15585/mmwr.mm6741a3.
7
Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2018 Recommendations of the International Antiviral Society-USA Panel.抗逆转录病毒药物治疗和预防成人 HIV 感染：美国国际抗病毒学会 2018 年推荐意见。
JAMA. 2018 Jul 24;320(4):379-396. doi: 10.1001/jama.2018.8431.
8
HIV Preexposure Prophylaxis as a Gateway to Primary Care.HIV 暴露前预防作为初级保健的切入点。
Am J Public Health. 2018 Oct;108(10):1418-1420. doi: 10.2105/AJPH.2018.304561. Epub 2018 Jul 19.
9
The prevalence of pre-exposure prophylaxis use and the pre-exposure prophylaxis-to-need ratio in the fourth quarter of 2017, United States.2017 年第四季度美国暴露前预防用药的使用情况和暴露前预防用药的需求比。
Ann Epidemiol. 2018 Dec;28(12):841-849. doi: 10.1016/j.annepidem.2018.06.005. Epub 2018 Jun 15.
10
The ANRS-Ipergay trial, an opportunity to use qualitative research to understand the perception of the "participant"-physician relationship.ANRS-Ipergay试验，这是一个利用定性研究来理解“参与者”与医生关系认知的契机。
AIDS Care. 2018 Jun;30(sup2):41-47. doi: 10.1080/09540121.2018.1468013. Epub 2018 May 30.
Zotero 插件