Department of Clinical and Biological Sciences, S. Luigi Gonzaga Hospital, University of Turin, Regione Gonzole 10, Orbassano, Turin, Italy.
Department of Medical Sciences, Laboratory of Clinical Pharmacology and Pharmacogenetics Padiglione Q, Amedeo di Savoia Hospital, University of Turin-ASL "Città di Torino", C.so Svizzera 164, Turin, Italy.
Eur J Drug Metab Pharmacokinet. 2020 Jun;45(3):405-412. doi: 10.1007/s13318-019-00603-6.
The broad-spectrum triazole antifungal agent, voriconazole, is widely used in the treatment of invasive fungal infections. Its treatment efficacy and the occurrence of adverse events are associated with plasma drug concentration, rendering inconsistent or inadequate dosing in many patients. The aim of this study was to evaluate the effect of gender, age, body mass index, ethnicity, serum creatinine and drug dose on voriconazole trough concentration.
A fully validated chromatographic method was used to quantify voriconazole concentration in plasma collected from adult patients at the end of dosing interval. Associations between variables were tested using the Pearson test. The Mann-Whitney U test was used to probe the influence of categorical variables on continuous ones.
In a cohort of 330 Italian patients treated with voriconazole, males reported a significantly higher drug concentration than females, with values higher than 1000 ng/mL. Moreover, in the univariate analysis, a significant correlation was found between trough concentration and increasing age.
Increasing age and gender could influence voriconazole trough concentrations.
广谱三唑类抗真菌药物伏立康唑广泛用于治疗侵袭性真菌感染。其治疗效果和不良反应的发生与血浆药物浓度有关，许多患者的剂量不一致或不足。本研究旨在评估性别、年龄、体重指数、种族、血清肌酐和药物剂量对伏立康唑谷浓度的影响。
使用完全验证的色谱法在给药间隔结束时从成年患者的血浆中定量伏立康唑浓度。使用 Pearson 检验测试变量之间的关联。Mann-Whitney U 检验用于探究分类变量对连续变量的影响。
在意大利 330 名接受伏立康唑治疗的患者队列中，男性报告的药物浓度明显高于女性，超过 1000ng/mL。此外，在单因素分析中，谷浓度与年龄的增加呈显著相关性。
年龄和性别可能会影响伏立康唑的谷浓度。
