Stoev Svetoslav, Lebanova Hristina
Department of Pharmaceutical Sciences and Social Pharmacy, Faculty of Pharmacy, Medical University Pleven, 5800 Pleven, Bulgaria.
Reports (MDPI). 2024 Nov 22;7(4):105. doi: 10.3390/reports7040105.
Voriconazole is a commonly prescribed second-generation azole used for the prevention and treatment of fungal infections. This report seeks to elucidate the relationship between certain intravenous infusion parameters and the causality and severity of potential visual adverse events associated with voriconazole administration, despite existing reports of visual disturbances such as hallucinations and altered visual perception, the underlying causes of which remain inadequately understood. This case report describes a 32-year-old female patient who experienced sudden hallucinations and visual impairments after receiving an initial dose of intravenous voriconazole for the treatment of recurrent severe vulvovaginitis caused by . The symptoms quickly disappeared when the dosage and infusion rate were reduced as per the recommendations of the clinical pharmacist. This example emphasizes the possible negative drug responses linked to voriconazole, especially those provoked by its irrational use described as an inappropriate infusion rate, and the crucial role of clinical pharmacists in recognizing and handling these reactions.
伏立康唑是一种常用的第二代唑类药物，用于预防和治疗真菌感染。本报告旨在阐明某些静脉输注参数与伏立康唑给药相关潜在视觉不良事件的因果关系和严重程度，尽管已有关于幻觉和视觉感知改变等视觉障碍的报道，但其潜在原因仍未得到充分了解。本病例报告描述了一名32岁女性患者，她在接受首剂静脉注射伏立康唑治疗由……引起的复发性严重外阴阴道炎后，突然出现幻觉和视力障碍。按照临床药师的建议降低剂量和输注速度后，症状迅速消失。这个例子强调了与伏立康唑相关的可能负面药物反应，特别是那些由不合理使用（如不适当的输注速度）引发的反应，以及临床药师在识别和处理这些反应中的关键作用。
