Wang Lixin, Chu Mingliang, Yin Dan, Cao Ying, Guan Zhizhong, Ma Xiaobo
Department of Pathology, Guizhou Provincial People's Hospital Guiyang, China.
Guizhou Medical University Guiyang, China.
Int J Clin Exp Pathol. 2017 Oct 1;10(10):10674-10680. eCollection 2017.
Gastric cancer (GC) is one of the most commonly diagnosed malignancies worldwide. CKIP-1 is a casein kinase-2 α-subunit (CK2α) interacting protein. Though previous reports have shown that CKIP-1 plays a critical role in several types of cancers, hardly there are any studies that examined the role of CKIP-1 in the progression of GC. Our present study aimed to investigate the role of CKIP-1 in GC. Results demonstrated low-level expression of CKIP-1 in GC tissues and cell lines. Moreover, knockdown of CKIP-1 promoted cell proliferation, migration, and invasion in GC cell lines, whereas CKIP-1 overexpression inhibited proliferation, migration, and invasion in the cells. Altogether, our data suggests that CKIP-1 may act as a novel tumor suppressor gene in GC and is related to GC differentiation.
胃癌（GC）是全球最常被诊断出的恶性肿瘤之一。CKIP-1是一种与酪蛋白激酶2α亚基（CK2α）相互作用的蛋白。尽管先前的报告表明CKIP-1在几种类型的癌症中起关键作用，但几乎没有任何研究探讨过CKIP-1在胃癌进展中的作用。我们目前的研究旨在调查CKIP-1在胃癌中的作用。结果表明，CKIP-1在胃癌组织和细胞系中表达水平较低。此外，敲低CKIP-1可促进胃癌细胞系的细胞增殖、迁移和侵袭，而CKIP-1过表达则抑制细胞的增殖、迁移和侵袭。总之，我们的数据表明CKIP-1可能作为一种新的肿瘤抑制基因参与胃癌发生，并与胃癌分化相关。
