Zhang Xiaojie, Li Yuanyuan, Li Xiaoxu, Ren Xianyue, Xia Juan, Wang Zhi, Cheng Bin, Wang Yun
Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University Guangzhou, Guangdong, China.
Int J Clin Exp Pathol. 2017 Nov 1;10(11):10947-10958. eCollection 2017.
Oral squamous cell carcinoma (OSCC) is a common and aggressively malignant tumor of the head and neck region. Long non-coding RNAs (lncRNAs) are important regulatory molecules in many types of cancer. However, there are limited studies on the role of lncRNAs in OSCC. In this study, we identified that lncRNA P4713 was one of the most up-regulated lncRNAs in OSCC by exploring the expression profile of lncRNAs/mRNAs in four pairs of OSCC samples and adjacent non-cancer tissues. In addition, silencing of P4713 inhibited OSCC proliferation, migration, and invasion . Furthermore, through bioinformatics analysis and functional experiments, we found that decreased P4713 expression affected the expression and phosphorylation of Janus Kinase (JAK) 2 and signal transducer and activator of transcription (STAT) 3. Taken together, the results suggest that P4713 contributes to OSCC cell proliferation, migration, and invasion by activating the JAK/STAT3 pathway. Accordingly, this molecule could be a potential biomarker and therapeutic target in the treatment of OSCC.
口腔鳞状细胞癌（OSCC）是头颈部常见的侵袭性恶性肿瘤。长链非编码RNA（lncRNA）是多种癌症中的重要调控分子。然而，关于lncRNA在OSCC中的作用的研究有限。在本研究中，我们通过探索四对OSCC样本和相邻非癌组织中lncRNAs/mRNAs的表达谱，确定lncRNA P4713是OSCC中上调最为明显的lncRNA之一。此外，沉默P4713可抑制OSCC的增殖、迁移和侵袭。此外，通过生物信息学分析和功能实验，我们发现P4713表达降低会影响Janus激酶（JAK）2和信号转导及转录激活因子（STAT）3的表达和磷酸化。综上所述，结果表明P4713通过激活JAK/STAT3通路促进OSCC细胞的增殖、迁移和侵袭。因此，该分子可能是OSCC治疗中的潜在生物标志物和治疗靶点。
