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HOTAIR是甲状腺癌患者中一种很有前景的新型生物标志物。

HOTAIR is a promising novel biomarker in patients with thyroid cancer.

作者信息

Zhang Yifei, Yu Sui, Jiang Lixin, Wang Xixun, Song Xiaojing

机构信息

Department of Thyroid and Gastrointestinal Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College, Yantai, Shandong 264000, P.R. China.

Department of Endocrinology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College, Yantai, Shandong 264000, P.R. China.

出版信息

Exp Ther Med. 2017 May;13(5):2274-2278. doi: 10.3892/etm.2017.4231. Epub 2017 Mar 17.

DOI:10.3892/etm.2017.4231
PMID:28565838
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5443297/
Abstract

Thyroid cancer (TC) is the most common endocrine malignancy. Lack of effective early diagnostic tools is one of the clinical obstacles for TC treatment. Thus, enhanced comprehension of the molecular changes in TC tumorigenesis is urgently needed to develop novel strategies for the diagnosis and treatment of TC. Long non-coding RNAs (lncRNAs) manage fundamental biochemical and cellular processes in tumorigenesis and development. One of the best-described lncRNAs, HOX transcript antisense RNA (HOTAIR), functions as a regulatory molecule in a wide variety of biological processes, and represses gene expression through recruitment of the chromatin modifying complex. However, the function of HOTAIR in TC remains unclear. In the current study, the expression of HOTAIR is elevated in TC and correlates with metastasis and poor prognosis. Furthermore, the expression of HOTAIR is significantly upregulated in human thyroid carcinoma cells compared with normal human thyroid cells. Furthermore, knockdown of HOTAIR significantly inhibited cell growth and invasion in TPC-1 and SW579 human thyroid carcinoma. In summary, HOTAIR is a promising novel biomarker in patients with TC.

摘要

甲状腺癌（TC）是最常见的内分泌恶性肿瘤。缺乏有效的早期诊断工具是TC治疗的临床障碍之一。因此，迫切需要增强对TC肿瘤发生过程中分子变化的理解，以开发TC诊断和治疗的新策略。长链非编码RNA（lncRNA）在肿瘤发生和发展过程中调控基本的生化和细胞过程。其中描述得最为详尽的lncRNA之一，HOX转录本反义RNA（HOTAIR），在多种生物学过程中作为调节分子发挥作用，并通过募集染色质修饰复合物来抑制基因表达。然而，HOTAIR在TC中的功能仍不清楚。在本研究中，HOTAIR在TC中的表达升高，且与转移和不良预后相关。此外，与正常人类甲状腺细胞相比，HOTAIR在人甲状腺癌细胞中的表达显著上调。此外，敲低HOTAIR可显著抑制TPC-1和SW579人甲状腺癌细胞的生长和侵袭。总之，HOTAIR是TC患者中一种有前景的新型生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7031/5443297/435793fbfd22/etm-13-05-2274-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7031/5443297/a0813822b6aa/etm-13-05-2274-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7031/5443297/926b4ed16ff8/etm-13-05-2274-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7031/5443297/c2feeaf5822e/etm-13-05-2274-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7031/5443297/435793fbfd22/etm-13-05-2274-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7031/5443297/a0813822b6aa/etm-13-05-2274-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7031/5443297/926b4ed16ff8/etm-13-05-2274-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7031/5443297/c2feeaf5822e/etm-13-05-2274-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7031/5443297/435793fbfd22/etm-13-05-2274-g03.jpg

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Long non-coding RNA HOTAIR: A novel oncogene (Review).长链非编码RNA HOTAIR：一种新型癌基因（综述）。
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Expression Indicates Lymph Node Metastasis and Presence of Cancer-Associated Fibroblasts in Papillary Thyroid Cancer.表达表明在甲状腺乳头状癌中存在淋巴结转移和癌症相关成纤维细胞。
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