Abudesimu Asiya, Adi Dilare, Siti Dilixiati, Ma Xiang, Liu Fen, Xie Xiang, Yang Yining, Li Xiaomei, Chen Bangdang, Ma Yitong, Fu Zhenyan
Department of Cardiovascular Medicine, First Affiliated Hospital of Xinjiang Medical University Urumqi, PR China.
Xinjiang Key Laboratory of Cardiovascular Disease, Clinical Medical Research Institute of First Affiliated Hospital of Xinjiang Medical University Urumqi, PR China.
Int J Clin Exp Pathol. 2017 Nov 1;10(11):11179-11187. eCollection 2017.
Hyperlipidemia is a major risk factor for coronary artery disease (CAD). As F-box and WD repeat domain-containing 7 (FBXW7) gene is an important regulating factor for lipid metabolism, the aim of the present study is to assess the association between human FBXW7 gene polymorphisms and CAD among Han Chinese and Uygur Chinese populations in Xinjiang, China.
A total of 1,312 Han Chinese (650 CAD patients and 662 controls) and 834 Uygur Chinese (414 CAD patients and 420 controls) were enrolled in this case-control study. Three single nucleotide polymorphisms (SNPs) rs2255137 T>C, rs2292743 A>T, rs35311955 G>C of FBXW7 were selected and genotyped using the improved multiplex ligase detection reaction (iMLDR) method.
We found that the rs2255137 CC genotype was very common in the CAD patients compared with the control subjects in the Uygur Chinese populations. After adjustments for several confounders: age, gender, smoking, drinking, hypertension, diabetes, TG, TC, HDL-C and LDL-C, this association remained significant. Furthermore, we investigated the relationships between rs2255137 genotypes and the circulating serum lipid levels and found that people carrying the C allele of rs2255137 may have higher serum lipid levels in the Uygur Chinese populations.
Our results indicate that rs2255137 in FBXW7 gene is associated with CAD in the Uygur Chinese population in China.
高脂血症是冠状动脉疾病（CAD）的主要危险因素。由于含F盒和WD重复结构域7（FBXW7）基因是脂质代谢的重要调节因子，本研究旨在评估中国新疆汉族和维吾尔族人群中人类FBXW7基因多态性与CAD之间的关联。
本病例对照研究共纳入1312名汉族人（650例CAD患者和662例对照）和834名维吾尔族人（414例CAD患者和420例对照）。选择FBXW7的三个单核苷酸多态性（SNP）rs2255137 T>C、rs2292743 A>T、rs35311955 G>C，并使用改进的多重连接检测反应（iMLDR）方法进行基因分型。
我们发现，与维吾尔族人群中的对照受试者相比，rs2255137 CC基因型在CAD患者中非常常见。在对年龄、性别、吸烟、饮酒、高血压、糖尿病、甘油三酯、总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇等几个混杂因素进行调整后，这种关联仍然显著。此外，我们研究了rs2255137基因型与循环血清脂质水平之间的关系，发现携带rs2255137 C等位基因的人在维吾尔族人群中可能具有更高的血清脂质水平。
我们的结果表明，FBXW7基因中的rs2255137与中国维吾尔族人群中的CAD相关。
