Cohen J R, Schroder W, Mandell C, Wise L
Department of Surgery, Long Island Jewish Medical Center, New Hyde Park, NY 11042.
Ann Vasc Surg. 1988 Apr;2(2):133-7. doi: 10.1016/S0890-5096(06)60795-4.
The purpose of this study was to determine whether aortic elastase could be activated by distant operative trauma unrelated to direct aortic injury. One hundred rabbits were divided into five groups: group I - anesthesia only; group II - laparotomy only; group III - cecal resection; group IV - aortic mobilization; and group V - aortotomy with repair. Animals were sacrificed at one hour, three hours, six hours, one day, two days, and five days after surgery, and the aorta was analyzed for elastase activity. Operative trauma such as laparotomy, bowel resection, and mobilization of the aorta without direct aortic injury resulted in a significant increase in rabbit aortic elastase. The pattern of activation of rabbit aortic elastase within the laparotomy, aortic mobilization, and aortotomy groups was one of a slow rise to peak activation at 6-24 hours with a subsequent fall towards baseline at five days after surgery. This pattern differed in the cecal resection group in which activation occurred immediately with a slow fall towards baseline at five days. In none of the four surgical groups did the elastase activity return to baseline by five days after surgery. These data suggest that aortic elastase in rabbits can be activated by intraabdominal surgery unrelated to direct aortic injury.
本研究的目的是确定主动脉弹性蛋白酶是否能被与直接主动脉损伤无关的远处手术创伤激活。100只兔子被分为五组：第一组——仅麻醉；第二组——仅开腹手术；第三组——盲肠切除术；第四组——主动脉游离术；第五组——主动脉切开术并修复。在术后1小时、3小时、6小时、1天、2天和5天处死动物，分析主动脉的弹性蛋白酶活性。诸如开腹手术、肠切除术以及在未直接损伤主动脉的情况下游离主动脉等手术创伤导致兔主动脉弹性蛋白酶显著增加。开腹手术组、主动脉游离术组和主动脉切开术组中兔主动脉弹性蛋白酶的激活模式是在术后6 - 24小时缓慢上升至激活峰值，随后在术后5天降至基线水平。这种模式在盲肠切除术组有所不同，该组激活立即发生，在术后5天缓慢降至基线水平。在四个手术组中，术后5天弹性蛋白酶活性均未恢复至基线水平。这些数据表明，兔主动脉弹性蛋白酶可被与直接主动脉损伤无关的腹部手术激活。
