Cohen J R, Sarfati I, Wise L
Department of Surgery, Long Island Jewish Medical Center, New Hyde Park, NY 11042.
J Vasc Surg. 1989 Apr;9(4):580-2.
Twenty rabbits were divided into three groups: (1) cage controls, (2) machine controls, and (3) cigarette exposed. The cigarette-exposed group was exposed to two 2-R1 reference cigarettes a day for 6 weeks on a Walton-II (Process and Instruments Corp., Brooklyn, N.Y.) smoking machine. Rabbits in the machine control group were placed in the smoking machine for the same period of time without cigarettes. Cage control animals were not placed in the smoking machine. Aortic elastase was significantly higher in the cigarette-exposed group (21.11 +/- 6.15) compared to both the cage control group (3.11 +/- 1.11) and machine control group (14.66 +/- 4.69). Aortic elastase in the machine control group was significantly higher in smoke-exposed rabbits than in both cage control and machine control rabbits. These data indicate that cigarette smoking increases aortic elastase activity in rabbits. If these data were to be extrapolated to humans, then patients with abdominal aortic aneurysms who smoke may have an accelerated rate of aneurysm growth or earlier rupture or both.
20只兔子被分为三组：（1）笼养对照组，（2）机器对照组，（3）香烟暴露组。香烟暴露组在一台沃尔顿-II型（纽约布鲁克林的Process and Instruments Corp.公司生产）吸烟机上，每天暴露于两支2-R1参比香烟，持续6周。机器对照组的兔子在相同时间段内被置于吸烟机中，但不接触香烟。笼养对照组的动物不被置于吸烟机中。与笼养对照组（3.11±1.11）和机器对照组（14.66±4.69）相比，香烟暴露组的主动脉弹性蛋白酶显著更高（21.11±6.15）。在机器对照组中，暴露于烟雾的兔子的主动脉弹性蛋白酶显著高于笼养对照组和机器对照组的兔子。这些数据表明，吸烟会增加兔子主动脉弹性蛋白酶的活性。如果将这些数据外推至人类，那么吸烟的腹主动脉瘤患者可能会有动脉瘤生长加速或更早破裂，或两者兼有的情况。
