Ye Yunxia, Zhang Wenyan, Zhao Sha, Jiang Lili, Liu Weiping, Long Yanhong, Wan Ying
Department of Pathology, West China Hospital of Sichuan University Chengdu, Sichuan Province, China.
Int J Clin Exp Pathol. 2017 Aug 1;10(8):8858-8862. eCollection 2017.
High-grade B-cell lymphoma with and rearrangements is a rare lymphoma which has highly aggressive clinical manifestations. The reporting case is a 72-year-old female presented with lumbago and weakness in the lower limb due to a mass at T8-10 revealed by computed tomography (CT) scan. Histological feature of the lesion shows an abundant and diffuse large lymphoid cells infiltration. Immunophenotype meets with germ center B cell (GCB) lymphoma (Hans algorithm). and gene rearrangements are detected by fluorescence in situ hybridization (FISH). It's a rare and typical case of high-grade B-cell lymphoma with and rearrangements with uncommon clinical manifestation.
伴有 MYC 和 BCL2 重排的高级别 B 细胞淋巴瘤是一种罕见的淋巴瘤，具有高度侵袭性的临床表现。报告的病例是一名 72 岁女性，因计算机断层扫描（CT）显示 T8 - 10 处有肿块而出现腰痛和下肢无力。病变的组织学特征显示有大量弥漫性大淋巴细胞浸润。免疫表型符合生发中心 B 细胞（GCB）淋巴瘤（汉斯算法）。通过荧光原位杂交（FISH）检测到 MYC 和 BCL2 基因重排。这是一例罕见且典型的伴有 MYC 和 BCL2 重排的高级别 B 细胞淋巴瘤，临床表现不常见。
