Manevska Nevena, Stojanoski Sinisa, Makazlieva Tanja, Jovanovska Anamarija
AACE Clin Case Rep. 2019 Jun 26;5(5):e311-e315. doi: 10.4158/ACCR-2018-0593. eCollection 2019 Sep-Oct.
Radioiodine ablation with iodine-131 is a standard therapeutic procedure for patients diagnosed with differentiated thyroid carcinoma (DTC). We present a contamination artifact on whole-body scan (WBS), after radioiodine ablation due to papillary thyroid carcinoma. The hybrid imaging resolved the question of metastasis versus contamination.
In the case of 35-year-old female patient we used a General Electric hybrid gamma camera with a high-energy-general-purpose collimator for performing WBS, and single photon emission computed tomography combined with low dose computed tomography (SPECT/CT) for the detection of any residual thyroid tissue or meta-static disease and at the same time ablation and treatment of any confirmed metastasis.
A thyroid scan showed activity in the remnant thyroid tissue of the right lobe, but also laterally in the calvaria (left temporal region). The patient's neck ultra-sound and thyroglobulin level were not in favor of metastasis. A false positive finding due to hair coloring was concluded with SPECT/CT hybrid imaging.
SPECT/CT scan can contribute to establishing a final diagnosis in patients being evaluated for atypical locations of radioactive iodine accumulation after ablative doses of radioactive iodine, distinguishing between metastases from DTC and false positive accumulations or artifacts.
对于诊断为分化型甲状腺癌(DTC)的患者,使用碘 - 131进行放射性碘消融是一种标准治疗方法。我们展示了一例因甲状腺乳头状癌进行放射性碘消融后全身扫描(WBS)出现的污染伪影。混合成像解决了转移与污染的问题。
对于一名35岁女性患者,我们使用配备高能通用准直器的通用电气混合伽马相机进行全身扫描,并使用单光子发射计算机断层扫描结合低剂量计算机断层扫描(SPECT/CT)来检测任何残留甲状腺组织或转移病灶,同时对任何确诊的转移灶进行消融和治疗。
甲状腺扫描显示右叶残余甲状腺组织有放射性,但在颅骨(左颞区)外侧也有。患者的颈部超声和甲状腺球蛋白水平不支持转移。通过SPECT/CT混合成像得出是由于染发导致的假阳性结果。
对于接受放射性碘消融剂量后评估放射性碘异常聚集非典型部位的患者,SPECT/CT扫描有助于做出最终诊断,区分DTC转移灶与假阳性聚集或伪影。