Percher Florent, Vidy Aurore, Gessain Antoine, Ceccaldi Pierre-Emmanuel, Afonso Philippe-V
Unité épidémiologie et physiopathologie des virus oncogènes, Institut Pasteur, 25, rue du Dr Roux, 75015 Paris, France, CNRS UMR 3569, 25, rue du docteur Roux, 75015 Paris, France, Cellule Pasteur, Université Paris-Paris 7, Sorbonne Paris Cité, 5 rue Thomas-Mann, 75013 Paris, France.
Unité épidémiologie et physiopathologie des virus oncogènes, Institut Pasteur, 25, rue du Dr Roux, 75015 Paris, France, CNRS UMR 3569, 25, rue du docteur Roux, 75015 Paris, France.
Virologie (Montrouge). 2017 Feb 1;21(1):11-18. doi: 10.1684/vir.2016.0675.
HTLV-1 (Human T-cell Lymphotropic Virus Type 1) is a human retrovirus that infects around 10 million people worldwide. It can be transmitted by sexual contact, transfusion of contaminated blood, and from infected mother-to-child during prolonged breastfeeding. The latter involves viral crossing of the digestive tract. HTLV-1 is the etiological agent of both a lymphoproliferative malignancy, Adult T-cell leukemia/lymphoma, and a chronic inflammatory neuromyelopathy, the Tropical Spastic Paraparesis/HTLV-1 Associated Myelopathy (TSP/HAM). TSP/HAM is characterized by HTLV-1-infected lymphocyte infiltration in the central nervous system; these cells cross the blood-brain barrier, an anatomical barrier that normally isolates and protects the central nervous system from blood. In this context, the present review focuses on latest findings and opinions on the interactions of HTLV-1 with the intestinal barrier, as involved in mother-to-child viral transmission, and with the blood-brain barrier, as involved in TSP/HAM pathogenesis.
人类嗜T淋巴细胞病毒1型（HTLV-1）是一种人类逆转录病毒，全球约有1000万人感染该病毒。它可通过性接触、输注受污染血液以及在长期母乳喂养期间由受感染的母亲传播给孩子。后者涉及病毒穿过消化道。HTLV-1是淋巴增生性恶性肿瘤成人T细胞白血病/淋巴瘤和慢性炎性神经脊髓病热带痉挛性截瘫/HTLV-1相关脊髓病（TSP/HAM）的病原体。TSP/HAM的特征是HTLV-1感染的淋巴细胞浸润中枢神经系统；这些细胞穿过血脑屏障，血脑屏障是一种解剖学屏障，通常可隔离并保护中枢神经系统免受血液侵害。在此背景下，本综述重点关注HTLV-1与肠道屏障（涉及母婴病毒传播）以及与血脑屏障（涉及TSP/HAM发病机制）相互作用的最新研究结果和观点。
