Percher Florent, Jeannin Patricia, Martin-Latil Sandra, Gessain Antoine, Afonso Philippe V, Vidy-Roche Aurore, Ceccaldi Pierre-Emmanuel
Pasteur Institute, Virology Department, Epidemiology and Physiopathology of Oncogenic Viruses Unit, F-75015 Paris, France.
UMR CNRS 3569, Paris 75015, France.
Viruses. 2016 Feb 3;8(2):40. doi: 10.3390/v8020040.
Human T-cell Lymphotropic Virus type 1 (HTLV-1) is a human retrovirus that infects at least 5-10 million people worldwide, and is the etiological agent of a lymphoproliferative malignancy; Adult T-cell Leukemia/Lymphoma (ATLL); and a chronic neuromyelopathy, HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP), as well as other inflammatory diseases such as infective dermatitis and uveitis. Besides sexual intercourse and intravenous transmission, HTLV-1 can also be transmitted from infected mother to child during prolonged breastfeeding. Some characteristics that are linked to mother-to-child transmission (MTCT) of HTLV-1, such as the role of proviral load, antibody titer of the infected mother, and duration of breastfeeding, have been elucidated; however, most of the mechanisms underlying HTLV-1 transmission during breast feeding remain largely unknown, such as the sites of infection and cellular targets as well as the role of milk factors. The present review focuses on the latest findings and current opinions and perspectives on MTCT of HTLV-1.
人类嗜T细胞病毒1型（HTLV-1）是一种人类逆转录病毒，全球至少有500万至1000万人感染该病毒，它是一种淋巴细胞增生性恶性肿瘤——成人T细胞白血病/淋巴瘤（ATLL）以及一种慢性神经脊髓病——HTLV-1相关脊髓病/热带痉挛性截瘫（HAM/TSP）的病原体，此外还会引发其他炎症性疾病，如感染性皮炎和葡萄膜炎。除了性传播和静脉传播外，HTLV-1在长时间母乳喂养期间也可由感染母亲传播给孩子。一些与HTLV-1母婴传播（MTCT）相关的特征，如前病毒载量的作用、感染母亲的抗体滴度以及母乳喂养持续时间等已得到阐明；然而，母乳喂养期间HTLV-1传播的大多数潜在机制仍不清楚，如感染部位、细胞靶点以及乳汁因子的作用等。本综述重点关注HTLV-1母婴传播的最新研究结果以及当前的观点和看法。
