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Carotid Intima-Media Thickness: Novel Loci, Sex-Specific Effects, and Genetic Correlations With Obesity and Glucometabolic Traits in UK Biobank.颈动脉内中膜厚度：英国生物库中肥胖和糖代谢特征的新基因座、性别特异性效应及遗传相关性
Arterioscler Thromb Vasc Biol. 2020 Feb;40(2):446-461. doi: 10.1161/ATVBAHA.119.313226. Epub 2019 Dec 5.
2
Sequence variants with large effects on cardiac electrophysiology and disease.对心脏电生理学和疾病有较大影响的序列变异。
Nat Commun. 2019 Oct 22;10(1):4803. doi: 10.1038/s41467-019-12682-9.
3
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.GWAS 和共定位分析提示颈动脉内膜中层厚度和颈动脉斑块部位与心血管结局相关。
Nat Commun. 2018 Dec 3;9(1):5141. doi: 10.1038/s41467-018-07340-5.
4
Identification of a 3'-Untranslated Genetic Variant of RARB Associated With Carotid Intima-Media Thickness in Rheumatoid Arthritis: A Genome-Wide Association Study.鉴定与类风湿关节炎颈动脉内膜中层厚度相关的 RARB 3'非翻译区遗传变异：全基因组关联研究。
Arthritis Rheumatol. 2019 Mar;71(3):351-360. doi: 10.1002/art.40734. Epub 2019 Jan 18.
5
A decade of genome-wide association studies for coronary artery disease: the challenges ahead.一项针对冠心病的全基因组关联研究十年：未来的挑战。
Cardiovasc Res. 2018 Jul 15;114(9):1241-1257. doi: 10.1093/cvr/cvy084.
6
Genome-wide admixture and association study of subclinical atherosclerosis in the Women's Interagency HIV Study (WIHS).女性机构间HIV研究（WIHS）中亚临床动脉粥样硬化的全基因组混合与关联研究。
PLoS One. 2017 Dec 4;12(12):e0188725. doi: 10.1371/journal.pone.0188725. eCollection 2017.
7
ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte Transmigration.与ADAM10相互作用的四跨膜蛋白Tspan5和Tspan17调节血管内皮钙黏蛋白的表达并促进T淋巴细胞迁移。
J Immunol. 2017 Jul 15;199(2):666-676. doi: 10.4049/jimmunol.1600713. Epub 2017 Jun 9.
8
Admixture Mapping of Subclinical Atherosclerosis and Subsequent Clinical Events Among African Americans in 2 Large Cohort Studies.两项大型队列研究中非洲裔美国人亚临床动脉粥样硬化及后续临床事件的混合映射
Circ Cardiovasc Genet. 2017 Apr;10(2). doi: 10.1161/CIRCGENETICS.116.001569.
9
Genome-wide meta-analysis identifies novel loci of plaque burden in carotid artery.全基因组荟萃分析确定了颈动脉斑块负荷的新基因座。
Atherosclerosis. 2017 Apr;259:32-40. doi: 10.1016/j.atherosclerosis.2017.02.018. Epub 2017 Feb 24.
10
Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis.亚临床动脉粥样硬化的多民族外显子组全关联研究
Circ Cardiovasc Genet. 2016 Dec;9(6):511-520. doi: 10.1161/CIRCGENETICS.116.001572. Epub 2016 Nov 21.

Making Novel Genetic Associations With Carotid Intima-Media Thickness Using the UK Biobank.

作者信息

Guo Liang, Cornelissen Anne, Sakamoto Atsushi, Finn Aloke V

机构信息

From the CVPath Institute, Gaithersburg, MD (L.G., A.C., A.S., A.V.F.).

Department of Medicine, University of Maryland School of Medicine, Baltimore (A.V.F.).

出版信息

Arterioscler Thromb Vasc Biol. 2020 Feb;40(2):297-300. doi: 10.1161/ATVBAHA.119.313784. Epub 2020 Jan 22.

DOI:10.1161/ATVBAHA.119.313784
PMID:31967906
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7033653/
Abstract
摘要