用 P-选择素缺陷小鼠来研究镰状细胞病的病理生理学。
P-selectin-deficient mice to study pathophysiology of sickle cell disease.
机构信息
Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Department of Chemical and Biomedical Engineering, West Virginia University, Morgantown, WV.
出版信息
Blood Adv. 2020 Jan 28;4(2):266-273. doi: 10.1182/bloodadvances.2019000603.
Abstract
P-selectin–deficient SCD mice are protected from lung vaso-occlusion. P-selectin–deficient SCD mice will be useful in assessing the benefits of anti–P-selectin therapy in diverse complications of SCD.
摘要
P 选择素缺陷 SCD 小鼠可预防肺部血管阻塞。P 选择素缺陷 SCD 小鼠将有助于评估抗 P 选择素疗法在 SCD 多种并发症中的获益。
相似文献
1
P-selectin-deficient mice to study pathophysiology of sickle cell disease.用 P-选择素缺陷小鼠来研究镰状细胞病的病理生理学。
Blood Adv. 2020 Jan 28;4(2):266-273. doi: 10.1182/bloodadvances.2019000603.
2
P-selectin deficiency promotes liver senescence in sickle cell disease mice.P 选择素缺乏促进镰状细胞病小鼠肝脏衰老。
Blood. 2021 May 13;137(19):2676-2680. doi: 10.1182/blood.2020009779.
3
The contribution of endothelial cell P-selectin to the microvascular flow of mouse sickle erythrocytes in vivo.内皮细胞P-选择素对小鼠体内镰状红细胞微血管血流的作用。
Blood. 2004 Nov 15;104(10):3378-85. doi: 10.1182/blood-2004-02-0713. Epub 2004 Jul 22.
4
Inhibition of cell adhesion by anti-P-selectin aptamer: a new potential therapeutic agent for sickle cell disease.抗 P-选择素适体抑制细胞黏附：镰状细胞病的一种新的潜在治疗药物。
Blood. 2011 Jan 13;117(2):727-35. doi: 10.1182/blood-2010-05-285718. Epub 2010 Oct 6.
5
Cellular adhesion and the endothelium: P-selectin.细胞黏附与内皮：P-选择素
Hematol Oncol Clin North Am. 2014 Apr;28(2):323-39. doi: 10.1016/j.hoc.2013.11.007. Epub 2014 Jan 17.
6
P-selectin mediates the adhesion of sickle erythrocytes to the endothelium.P选择素介导镰状红细胞与内皮细胞的黏附。
Blood. 2001 Sep 15;98(6):1955-62. doi: 10.1182/blood.v98.6.1955.
7
Physical activity limits pulmonary endothelial activation in sickle cell SAD mice.体育活动可限制镰状细胞性睡眠呼吸暂停（SAD）小鼠的肺内皮细胞激活。
Blood. 2014 Apr 24;123(17):2745-7. doi: 10.1182/blood-2013-10-534982.
8
Hypoxia/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice.缺氧/复氧在转基因镰状小鼠中引发炎症反应，但在正常小鼠中则不会。
J Clin Invest. 2000 Aug;106(3):411-20. doi: 10.1172/JCI9225.
9
P-selectin plays a role in haem-induced acute lung injury in sickle mice.P-选择素在镰状小鼠血红蛋白诱导的急性肺损伤中起作用。
Br J Haematol. 2019 Jul;186(2):329-333. doi: 10.1111/bjh.15807. Epub 2019 Feb 27.
10
Crizanlizumab: First Approval.西尼兰单抗：首次获批
Drugs. 2020 Jan;80(1):79-84. doi: 10.1007/s40265-019-01254-2.
引用本文的文献
1
Hemoglobin scavenger receptor CD163 as a potential biomarker of hemolysis-induced hepatobiliary injury in sickle cell disease.血红蛋白清道夫受体 CD163 作为镰状细胞病溶血诱导肝胆损伤的潜在生物标志物。
Am J Physiol Cell Physiol. 2024 Aug 1;327(2):C423-C437. doi: 10.1152/ajpcell.00386.2023. Epub 2024 Apr 29.
2
From Stress to Sick(le) and Back Again-Oxidative/Antioxidant Mechanisms, Genetic Modulation, and Cerebrovascular Disease in Children with Sickle Cell Anemia.从应激到镰状细胞病再回归——镰状细胞贫血患儿的氧化/抗氧化机制、基因调控与脑血管疾病
Antioxidants (Basel). 2023 Nov 7;12(11):1977. doi: 10.3390/antiox12111977.
3
Impaired hemoglobin clearance by sinusoidal endothelium promotes vaso-occlusion and liver injury in sickle cell disease.窦内皮细胞对血红蛋白清除能力受损可促进镰状细胞病中的血管阻塞和肝损伤。
Haematologica. 2024 May 1;109(5):1535-1550. doi: 10.3324/haematol.2023.283792.
4
Hemolysis dictates monocyte differentiation via two distinct pathways in sickle cell disease vaso-occlusion.溶血通过两条不同途径在镰状细胞病血管阻塞中决定单核细胞分化。
J Clin Invest. 2023 Sep 15;133(18):e172087. doi: 10.1172/JCI172087.
5
Molecular mechanisms of hepatic dysfunction in sickle cell disease: lessons from Townes mouse model.镰状细胞病肝功能障碍的分子机制：来自 Townes 小鼠模型的启示。
Am J Physiol Cell Physiol. 2022 Aug 1;323(2):C494-C504. doi: 10.1152/ajpcell.00175.2022. Epub 2022 Jun 27.
6
Liver-to-lung microembolic NETs promote gasdermin D-dependent inflammatory lung injury in sickle cell disease.肝到肺的微栓子 NETs 通过依赖于 gasdermin D 的炎症反应促进镰状细胞病的肺部损伤。
Blood. 2022 Sep 1;140(9):1020-1037. doi: 10.1182/blood.2021014552.
7
Selectin-Mediated Signaling-Shedding Light on the Regulation of Integrin Activity in Neutrophils.选择素介导的信号转导——揭示中性粒细胞整合素活性的调节机制。
Cells. 2022 Apr 12;11(8):1310. doi: 10.3390/cells11081310.
8
Targeting Neutrophil Adhesive Events to Address Vaso-Occlusive Crisis in Sickle Cell Patients.靶向中性粒细胞黏附事件治疗镰状细胞病患者血管闭塞性危象。
Front Immunol. 2021 Apr 28;12:663886. doi: 10.3389/fimmu.2021.663886. eCollection 2021.
9
P-Selectin Blockade in the Treatment of Painful Vaso-Occlusive Crises in Sickle Cell Disease: A Spotlight on Crizanlizumab.P-选择素阻断剂在镰状细胞病疼痛性血管闭塞危象治疗中的应用：聚焦克立硐珠单抗
J Pain Res. 2021 Mar 30;14:849-856. doi: 10.2147/JPR.S278285. eCollection 2021.
10
Sickle cell vaso-occlusion: The dialectic between red cells and white cells.镰状细胞血管阻塞：红细胞与白细胞的辩证关系。
Exp Biol Med (Maywood). 2021 Jun;246(12):1458-1472. doi: 10.1177/15353702211005392. Epub 2021 Apr 1.
本文引用的文献
1
Platelet Extracellular Vesicles Drive Inflammasome-IL-1β-Dependent Lung Injury in Sickle Cell Disease.血小板细胞外囊泡驱动镰状细胞病中的炎性体-IL-1β 依赖性肺损伤。
Am J Respir Crit Care Med. 2020 Jan 1;201(1):33-46. doi: 10.1164/rccm.201807-1370OC.
2
Mast Cells Induce Blood Brain Barrier Damage in SCD by Causing Endoplasmic Reticulum Stress in the Endothelium.肥大细胞通过在内皮细胞中引起内质网应激，导致镰状细胞病中的血脑屏障损伤。
Front Cell Neurosci. 2019 Feb 19;13:56. doi: 10.3389/fncel.2019.00056. eCollection 2019.
3
Smooth Muscle Cells: A Novel Site of P-Selectin Expression with Pathophysiological and Therapeutic Relevance in Pulmonary Hypertension.平滑肌细胞：P-选择素表达的新位点，在肺动脉高压中具有病理生理学及治疗学意义
Am J Respir Crit Care Med. 2019 Jun 1;199(11):1307-1309. doi: 10.1164/rccm.201812-2242ED.
4
Evidence for the Fucoidan/P-Selectin Axis as a Therapeutic Target in Hypoxia-induced Pulmonary Hypertension.在缺氧性肺动脉高压中，作为治疗靶点的褐藻糖胶/P 选择素轴。
Am J Respir Crit Care Med. 2019 Jun 1;199(11):1407-1420. doi: 10.1164/rccm.201806-1170OC.
5
Pathophysiology of Sickle Cell Disease.镰状细胞病的病理生理学。
Annu Rev Pathol. 2019 Jan 24;14:263-292. doi: 10.1146/annurev-pathmechdis-012418-012838. Epub 2018 Oct 17.
6
Dysregulated Bile Transporters and Impaired Tight Junctions During Chronic Liver Injury in Mice.在慢性肝损伤过程中，小鼠的胆汁转运体失调和紧密连接受损。
Gastroenterology. 2018 Oct;155(4):1218-1232.e24. doi: 10.1053/j.gastro.2018.06.048. Epub 2018 Jun 30.
7
Sickle cell disease.镰状细胞病。
Nat Rev Dis Primers. 2018 Mar 15;4:18010. doi: 10.1038/nrdp.2018.10.
8
Dual catenin loss in murine liver causes tight junctional deregulation and progressive intrahepatic cholestasis.双重连环蛋白缺失导致小鼠肝脏紧密连接调节紊乱和进行性肝内胆汁淤积。
Hepatology. 2018 Jun;67(6):2320-2337. doi: 10.1002/hep.29585. Epub 2018 Apr 19.
9
Lung vaso-occlusion in sickle cell disease mediated by arteriolar neutrophil-platelet microemboli.镰状细胞病中的肺血管阻塞是由小动脉中性粒细胞-血小板微栓子介导的。
JCI Insight. 2017 Jan 12;2(1):e89761. doi: 10.1172/jci.insight.89761.
10
Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease.克立硃单抗用于预防镰状细胞病的疼痛危象
N Engl J Med. 2017 Feb 2;376(5):429-439. doi: 10.1056/NEJMoa1611770. Epub 2016 Dec 3.
Zotero 插件