Vasilets L A, Mokh V P, Plekhanova L G
Biull Eksp Biol Med. 1988 Nov;106(11):554-7.
At the experiments with the isolated rat hearts, prepared by Langendorff, the anti-arrhythmic dose-effects of the water-soluble antioxidant fenozan from the class of steric-hindrance phenols were studied at condition of regional ischemia and reperfusion, as well as its action on the coronary flow. 3.6.10(-4) M of fenozan completely inhibited ischemic tachycardias, and diminished their incidence during reperfusion to 27%. The action of the fenozan in the concentration one order less, diminished total amount of reperfusion fibrillation to 67% (compared to 100% in control), the incidence of the long fibrillation to 67%, and considerably shifted their beginning to the moment of reperfusion. Dose-effects of anti-arrhythmic action of the antioxidant was V-shaped. Introduction of fenozan before 10 minutes of the occlusion caused an 1.5-2 hold increase of the coronary flow. This data show an effective antiarrhythmic and vasodilator action of the water-soluble phenol antioxidants during acute ischemia and reperfusion of myocardium.
在用Langendorff制备的离体大鼠心脏进行的实验中，研究了空间位阻酚类的水溶性抗氧化剂非诺赞在局部缺血和再灌注条件下的抗心律失常剂量效应及其对冠状动脉血流的作用。3.6×10⁻⁴M的非诺赞完全抑制了缺血性心动过速，并将再灌注期间其发生率降低至27%。浓度低一个数量级的非诺赞的作用，将再灌注性颤动的总量降低至67%（对照组为100%），长时颤动的发生率降低至67%，并将其开始时间显著推迟至再灌注时刻。抗氧化剂抗心律失常作用的剂量效应呈V形。在闭塞前10分钟引入非诺赞使冠状动脉血流增加1.5 - 2倍。这些数据表明水溶性酚类抗氧化剂在心肌急性缺血和再灌注期间具有有效的抗心律失常和血管舒张作用。
