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Correlation of aromatase activity with histological differentiation of breast cancer--a morphometric analysis.

作者信息

Lipton A, Santen R J, Santner S J, Harvey H A, White-Hershey D, Bartholomew M J, Sharkey F E

机构信息

Department of Medicine, Pennsylvania State University, Hershey 17033.

出版信息

Breast Cancer Res Treat. 1988 Sep;12(1):31-5. doi: 10.1007/BF01805737.

DOI:10.1007/BF01805737
PMID:3196885
Abstract

Differentiation is a term that indicates the degree to which a tumor resembles histologically the tissue or cell of origin. A system to quantitate the proportion of breast cancer cells participating in glandular differentiation or remaining within ducts was employed. The degree of tumor differentiation of 58 primary breast cancers was correlated with estrogen (ER) and progesterone receptors (PR) and tumor aromatase activity. There was a significant association between tumor differentiation (greater than or equal to 2% cancer cells exhibiting glandular differentiation) and the presence of ER or PR in tumors. Conversely, there was no correlation between tumor differentiation and measurable tumor aromatase activity.

摘要

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Correlation of aromatase activity with histological differentiation of breast cancer--a morphometric analysis.
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引用本文的文献

1
Biological effects of stable overexpression of aromatase in human hormone-dependent breast cancer cells.芳香化酶在人激素依赖性乳腺癌细胞中稳定过表达的生物学效应。
Br J Cancer. 1994 Jan;69(1):77-83. doi: 10.1038/bjc.1994.12.
2
The role of aromatase in breast tumors.芳香化酶在乳腺肿瘤中的作用。
Breast Cancer Res Treat. 1994;30(1):7-17. doi: 10.1007/BF00682737.

本文引用的文献

1
Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years.乳腺癌的组织学分级与预后；对1409例病例的研究，其中359例已随访15年。
Br J Cancer. 1957 Sep;11(3):359-77. doi: 10.1038/bjc.1957.43.
2
The conversion of androstenedione to estrone, estradiol, and testosterone in breast tissue.
J Steroid Biochem. 1980 Jan;13(1):89-94. doi: 10.1016/0022-4731(80)90117-x.
3
Maternal stress decreases steroid aromatase activity in brains of male and female rat fetuses.母体应激会降低雄性和雌性大鼠胎儿大脑中的类固醇芳香化酶活性。
Neuroendocrinology. 1982 Nov;35(5):374-9. doi: 10.1159/000123410.
4
Methods and results of aromatization studies in vivo.体内芳香化研究的方法与结果。
Cancer Res. 1982 Aug;42(8 Suppl):3307s-3311s.
5
Review of studies on estrogen biosynthesis in the human.人体雌激素生物合成研究综述。
Cancer Res. 1982 Aug;42(8 Suppl):3269s-3273s.
6
Intralaboratory variations in the grading of breast carcinoma.乳腺癌分级的实验室内部差异。
Arch Pathol Lab Med. 1982 Mar;106(3):126-8.
7
Biological significance of aromatase activity in human breast tumors.人乳腺肿瘤中芳香化酶活性的生物学意义。
J Clin Endocrinol Metab. 1983 Dec;57(6):1125-8. doi: 10.1210/jcem-57-6-1125.
8
Morphometric analysis of differentiation in human breast carcinoma. Tumor heterogeneity.人乳腺癌分化的形态计量分析。肿瘤异质性。
Arch Pathol Lab Med. 1983 Aug;107(8):411-4.
9
Morphometric analysis of differentiation in human breast carcinoma. Tumor grading.人乳腺癌分化的形态计量分析。肿瘤分级。
Arch Pathol Lab Med. 1983 Aug;107(8):406-10.
10
Correlation of immunohistochemical markers with patient prognosis in breast carcinoma: a quantitative study.乳腺癌中免疫组化标志物与患者预后的相关性：一项定量研究。
Am J Clin Pathol. 1984 Nov;82(5):582-5. doi: 10.1093/ajcp/82.5.582.