Mehta Anita, Mishra Shambhavi, Ahmad Kaleem, Tiwari Harish Chandra, Singh Vijay, Singh Abhishek
Department of Paediatrics, BRD Medical College, Gorakhpur, India.
Department of Paediatrics, Grant Medical College and Sir Jamshedji Jijabhoy Group of Hospitals, Mumbai, Maharashtra, India.
Sudan J Paediatr. 2019;19(2):110-116. doi: 10.24911/SJP.106-1535804613.
Carotid intima media thickness (cIMT) is considered as a surrogate marker for the various cardiovascular events that complicate nephrotic syndrome (NS). The present work was conducted to study cIMT in children with NS and to find out its correlation with dyslipidemia and other risk factors. This was a case control study conducted at a tertiary care hospital in children with NS who were more than 2 years with normal serum complement, being on therapy for NS for at least 1 year, glomerular filtration rate more than 90 ml/minute/1.73 m and absence of acute infection in previous 3 months. Sixty six children with NS constituted the case material and 128 age and sex matched children were taken as control. The mean age in case and control cohort was 6.71 ± 3.3 and 7.89 ± 3.95 years, respectively. The mean age of onset of illness was 4.32 ± 2.25 years. The mean duration of illness was 2.39 ± 1.44 years. Thickness of cIMT was higher in NS children as compared to control group in all the ages, but this difference was statistically significant only after 4 years of age. There was statistically significant, but weak positive correlation between cIMT and age of NS children, duration of disease and number of relapses. There was no correlation of cIMT with hypertension, body mass index, serum creatinine, and dyslipidemia. A negative, but statistically insignificant correlation of cIMT was found with serum albumin and serum cholesterol.
颈动脉内膜中层厚度（cIMT）被视为肾病综合征（NS）并发的各种心血管事件的替代标志物。本研究旨在探讨NS患儿的cIMT，并找出其与血脂异常及其他危险因素的相关性。这是一项在三级护理医院进行的病例对照研究，研究对象为年龄超过2岁、血清补体正常、接受NS治疗至少1年、肾小球滤过率超过90 ml/分钟/1.73 m²且在过去3个月内无急性感染的NS患儿。66例NS患儿作为病例组，128例年龄和性别匹配的儿童作为对照组。病例组和对照组的平均年龄分别为6.71±3.3岁和7.89±3.95岁。发病的平均年龄为4.32±2.25岁。疾病的平均病程为2.39±1.44年。在所有年龄段，NS患儿的cIMT厚度均高于对照组，但仅在4岁以后这种差异具有统计学意义。cIMT与NS患儿的年龄、病程和复发次数之间存在统计学上显著但微弱的正相关。cIMT与高血压、体重指数、血清肌酐和血脂异常无关。cIMT与血清白蛋白和血清胆固醇呈负相关，但无统计学意义。
