New York University (NYU) Langone Medical Center, New York, New York 10016, USA.
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
J Biomol Tech. 2020 Apr;31(1):11-26. doi: 10.7171/jbt.20-3101-003.
Shared research resource facilities, also known as core laboratories (Cores), are responsible for generating a significant and growing portion of the research data in academic biomedical research institutions. Cores represent a central repository for institutional knowledge management, with deep expertise in the strengths and limitations of technology and its applications. They inherently support transparency and scientific reproducibility by protecting against cognitive bias in research design and data analysis, and they have institutional responsibility for the conduct of research (research ethics, regulatory compliance, and financial accountability) performed in their Cores. The Association of Biomolecular Resource Facilities (ABRF) is a FASEB-member scientific society whose members are scientists and administrators that manage or support Cores. The ABRF Research Groups (RGs), representing expertise for an array of cutting-edge and established technology platforms, perform multicenter research studies to determine and communicate best practices and community-based standards. This review provides a summary of the contributions of the ABRF RGs to promote scientific rigor and reproducibility in Cores from the published literature, ABRF meetings, and ABRF RGs communications.
共享研究资源设施，也称为核心实验室（Cores），负责生成学术生物医学研究机构中大量且不断增长的研究数据。Cores 是机构知识管理的核心存储库，拥有技术及其应用的优势和局限性方面的深厚专业知识。它们通过防止研究设计和数据分析中的认知偏差，从根本上支持透明度和科学可重复性，并且对在其核心中进行的研究负有机构责任（研究伦理、法规遵从性和财务问责制）。 生物分子资源设施协会（ABRF）是一个 FASEB 成员科学学会，其成员是管理或支持 Cores 的科学家和管理人员。ABRF 研究小组（RGs）代表一系列前沿和成熟技术平台的专业知识，进行多中心研究，以确定和交流最佳实践和基于社区的标准。 本综述从已发表的文献、ABRF 会议和 ABRF RGs 交流中，总结了 ABRF RGs 为促进 Cores 中的科学严谨性和可重复性所做的贡献。
