Gomar-Alba Mercè, Mendoza Manuel
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.
Centre National de la Recherche Scientifique, Illkirch, France.
Front Genet. 2020 Jan 8;10:1301. doi: 10.3389/fgene.2019.01301. eCollection 2019.
Nuclear pore complexes (NPCs) are protein assemblies that form channels across the nuclear envelope to mediate communication between the nucleus and the cytoplasm. Additionally, NPCs interact with chromatin and influence the position and expression of multiple genes. Interestingly, the composition of NPCs can vary in different cell-types, tissues, and developmental states. Here, we review recent findings suggesting that modifications of NPC composition, including post-translational modifications, play an instructive role in cell fate establishment. In particular, we focus on the role of cell-specific NPC deacetylation in asymmetrically dividing budding yeast, which modulates transport-dependent and transport-independent NPC functions to determine the time of commitment to a new division cycle in daughter cells. By modulating protein localization and gene expression, NPCs are therefore emerging as central regulators of cell identity.
核孔复合体（NPCs）是蛋白质组装体，它们在核膜上形成通道，以介导细胞核与细胞质之间的通讯。此外，核孔复合体与染色质相互作用，并影响多个基因的位置和表达。有趣的是，核孔复合体的组成在不同的细胞类型、组织和发育状态中可能会有所不同。在这里，我们回顾了最近的研究发现，这些发现表明核孔复合体组成的修饰，包括翻译后修饰，在细胞命运确立中发挥着指导作用。特别是，我们重点关注细胞特异性核孔复合体去乙酰化在不对称分裂的芽殖酵母中的作用，它调节依赖运输和不依赖运输的核孔复合体功能，以确定子细胞进入新分裂周期的时间。因此，通过调节蛋白质定位和基因表达，核孔复合体正逐渐成为细胞身份的核心调节因子。
