通过激活酵母中 VHS1 的顺式元件介导 Cd 耐受性，并增强白菜中 Cd 耐受性。
Mediates Cd Tolerance via Activation of the Cis Element of VHS1 in Yeast and Enhances Cd Tolerance in Chinese Cabbage.
机构信息
Shandong Key Laboratory of Bulk Open-Field Vegetable Breeding, Ministry of Agriculture and Rural Affairs Key Laboratory of Huang Huai Protected Horticulture Engineering, Institute of Vegetables, Shandong Academy of Agricultural Sciences, Jinan 250100, China.
Key Laboratory of Plant Development and Environment Adaptation Biology, Ministry of Education, School of Life Science, Shandong University, Qingdao 266237, China.
出版信息
Int J Mol Sci. 2024 Oct 14;25(20):11026. doi: 10.3390/ijms252011026.
Identifying key genes involved in Cadmium (Cd) response pathways in plants and developing low-Cd-accumulating cultivars may be the most effective and eco-friendly strategy to tackle the problem of Cd pollution in crops. In our previous study, () was identified to be associated with Cd tolerance in yeast. Here, we investigated the mechanism of in regulating Cd tolerance in yeast. ScSSA4 binds to POre Membrane 34 (POM34), a key component of nuclear pore complex (NPC), and translocates from the cytoplasm to the nucleus, where it regulates the expression of its downstream gene, (), resulting in reduced Cd accumulation in yeast cells. Additionally, we identified a Chinese cabbage gene, , which could enhance the Cd tolerance in Chinese cabbage. This study offers new insights into the regulatory mechanisms of Cd tolerance in yeast, a model organism, and paves the way for the genetic enhancement of Cd tolerance in Chinese cabbage.
在植物中鉴定参与镉（Cd）响应途径的关键基因，并开发低镉积累品种，可能是解决作物 Cd 污染问题最有效和最环保的策略。在我们之前的研究中，（）被鉴定与酵母中的 Cd 耐受性有关。在这里，我们研究了在酵母中调节 Cd 耐受性的机制。ScSSA4 与核孔复合体（NPC）的关键组成部分 POre Membrane 34（POM34）结合，并从细胞质转移到细胞核，在细胞核中，它调节其下游基因（）的表达，从而减少酵母细胞中 Cd 的积累。此外，我们鉴定了一个白菜基因，（），它可以增强白菜的 Cd 耐受性。这项研究为酵母这一模式生物中 Cd 耐受性的调控机制提供了新的见解，并为白菜 Cd 耐受性的遗传增强铺平了道路。
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