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冷冻消融肋间神经可减少胸主动脉或胸腹主动脉瘤修复术后的阿片类药物使用。

Cryoablation of Intercostal Nerves Decreased Narcotic Usage After Thoracic or Thoracoabdominal Aortic Aneurysm Repair.

机构信息

Department of Cardiac Surgery, Michigan Medicine, Ann Arbor, Michigan.

University of Michigan Medical School, Ann Arbor, Michigan.

出版信息

Semin Thorac Cardiovasc Surg. 2020;32(3):404-412. doi: 10.1053/j.semtcvs.2020.01.008. Epub 2020 Jan 20.

Abstract

To improve surgical pain control through cryoablation of intercostal nerves and reduce narcotic usage in patients undergoing open thoracic or thoracoabdominal aortic aneurysm (TAA or TAAA) repair. From 2012 to 2018, 117 patients underwent open repair of TAA or TAAA. Of those patients, 25 (21%) received cryoablation (2016-2018) of their intercostal nerves and 92 (79%) did not (2012-2018). The primary outcome was pain scores and narcotic usage from extubation day 1 to 10 or the day of discharge. The median age (57 years), demographics, and preoperative comorbidities were not significantly different between the 2 groups. The cryoablation group had significantly more incidences of thoracoabdominal incisions (52% vs 28%), urgent operations (32% vs 11%), and longer duration of chest tubes compared to the noncryoablation group (all P < 0.05). T9-T12 intercostal arteries were selectively reimplanted. Left intercostal nerves were cryoablated from T3 to T9 if 2 thoracotomies were used; or 2 intercostal spaces above and below the thoracotomy if 1 thoracotomy was used. There were no significant differences between the noncryoablation and cryoablation groups in postoperative stroke, paraplegia (5%), pneumonia, and in-hospital mortality (0.9%). However, the average usage of narcotics was significantly reduced in the cryoablation group by 28 measured morphine equivalents (equal to four 5 mg Oxycodone)/patient/day in 10 days after extubation, P = 0.005. With cryoablation of intercostal nerves, the postoperative surgical pain was well controlled and narcotic usage was significantly decreased after TAA or TAAA repair. Cryoablation of intercostal nerves was a safe and effective measure for postoperative pain control in TAA or TAAA repair.

摘要

通过冷冻肋间神经来改善手术疼痛控制,并减少接受开胸或胸腹主动脉瘤(TAA 或 TAAA)修复的患者的阿片类药物使用。2012 年至 2018 年,有 117 例患者接受了 TAA 或 TAAA 的开放修复。在这些患者中,25 例(21%)接受了肋间神经冷冻消融术(2016-2018 年),92 例(79%)未接受(2012-2018 年)。主要结果是从拔管第 1 天到第 10 天或出院当天的疼痛评分和阿片类药物使用量。两组患者的中位年龄(57 岁)、人口统计学特征和术前合并症无显著差异。冷冻消融组的胸腹联合切口发生率(52% vs 28%)、急诊手术发生率(32% vs 11%)和胸腔引流管放置时间均显著长于非冷冻消融组(均 P < 0.05)。选择性再植入 T9-T12 肋间动脉。如果使用了 2 个开胸切口,则从 T3 到 T9 冷冻消融左肋间神经;如果仅使用了 1 个开胸切口,则在开胸切口上方和下方的 2 个肋间空间冷冻消融左肋间神经。非冷冻消融组和冷冻消融组在术后中风、截瘫(5%)、肺炎和住院死亡率(0.9%)方面无显著差异。然而,冷冻消融组术后 10 天内阿片类药物的平均用量显著减少了 28 个吗啡等效物(相当于 4 个 5 mg 羟考酮/天),P = 0.005。冷冻消融肋间神经后,TAA 或 TAAA 修复后手术疼痛得到良好控制,阿片类药物使用显著减少。冷冻消融肋间神经是 TAA 或 TAAA 修复术后疼痛控制的一种安全有效的措施。

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