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冷冻消融对开胸手术患者手术结局的影响。

Impact of cryoablation on operative outcomes in thoracotomy patients.

作者信息

Pourak Kian, Kubiak Rachel, Arivoli Kumaran, Lagisetty Kiran, Lynch William, Lin Jules, Chang Andrew, Reddy Rishindra M

机构信息

University of Michigan Medical School, Ann Arbor, MI, USA.

Section of Thoracic Surgery, Department of Surgery, Michigan Medicine, Ann Arbor, MI, USA.

出版信息

Interdiscip Cardiovasc Thorac Surg. 2024 Feb 2;38(2). doi: 10.1093/icvts/ivae023.

Abstract

OBJECTIVES

Cryoablation is increasingly being utilized as an alternative to epidurals for patients undergoing thoracotomies. Current evidence suggests cryoablation may decrease postoperative analgesia utilization, but could increase operative times. We hypothesized that the adoption of intraoperative cryoablation to manage post-thoracotomy pain would result in reduced length of stay and reduced perioperative analgesia compared to routine epidural use.

METHODS

A retrospective analysis was performed from a single, quaternary referral centre, prospective database on patients receiving thoracotomies between January 2020 and March 2022. Patients undergoing transthoracic hiatal hernia repair, lung resection or double-lung transplant were divided between epidural and cryoablation cohorts. Primary outcomes were length of stay, intraoperative procedure time, crossover pain management and oral narcotic usage the day before discharge.

RESULTS

During the study period, 186 patients underwent a transthoracic hiatal hernia repair, lung resection or double-lung transplant with 94 receiving a preoperative epidural and 92 undergoing cryoablation. Subgroup analysis demonstrated no significant differences in demographics, operative length, length of stay or perioperative narcotic use. Notably, over a third of patients in each cryoablation subgroup received a postoperative epidural (45.5% transthoracic hiatal hernia repair, 38.5% lung resection and 45.0% double-lung transplant) for further pain management during their admission.

CONCLUSIONS

Cryoablation use was not associated with an increase in procedure time, a decrease in narcotic use or length of stay. Surprisingly, many cryoablation patients received epidurals in the postoperative period for further pain control. Additional analysis is needed to fully understand the benefits and costs of epidural versus cryoablation strategies.

摘要

目的

对于接受开胸手术的患者,冷冻消融术越来越多地被用作硬膜外麻醉的替代方法。目前的证据表明,冷冻消融术可能会减少术后镇痛药物的使用,但可能会延长手术时间。我们推测,与常规使用硬膜外麻醉相比,采用术中冷冻消融术来管理开胸术后疼痛将缩短住院时间并减少围手术期镇痛。

方法

对一家单一的四级转诊中心2020年1月至2022年3月期间接受开胸手术患者的前瞻性数据库进行回顾性分析。接受经胸裂孔疝修补术、肺切除术或双肺移植的患者被分为硬膜外麻醉组和冷冻消融组。主要结局指标为住院时间、术中手术时间、交叉疼痛管理以及出院前一天的口服麻醉药使用情况。

结果

在研究期间,186例患者接受了经胸裂孔疝修补术、肺切除术或双肺移植,其中94例接受了术前硬膜外麻醉,92例接受了冷冻消融术。亚组分析显示,在人口统计学、手术时长、住院时间或围手术期麻醉药使用方面无显著差异。值得注意的是,每个冷冻消融亚组中超过三分之一的患者在住院期间接受了术后硬膜外麻醉(经胸裂孔疝修补术患者为45.5%,肺切除术患者为38.5%,双肺移植患者为45.0%)以进一步控制疼痛。

结论

使用冷冻消融术与手术时间增加、麻醉药使用减少或住院时间缩短无关。令人惊讶的是,许多接受冷冻消融术的患者在术后接受了硬膜外麻醉以进一步控制疼痛。需要进行更多分析以全面了解硬膜外麻醉与冷冻消融术策略的益处和成本。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0ff/10898328/f5689cdf997b/ivae023f4.jpg

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