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肋间神经冷冻镇痛术可改善降主动脉和胸腹主动脉瘤修复术后的疼痛控制。

Intraoperative Intercostal Nerve Cryoanalgesia Improves Pain Control After Descending and Thoracoabdominal Aortic Aneurysm Repairs.

机构信息

Department of Cardiothoracic and Vascular Surgery, McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth) and Memorial Hermann Hospital, Houston, Texas.

Department of Cardiothoracic and Vascular Surgery, McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth) and Memorial Hermann Hospital, Houston, Texas.

出版信息

Ann Thorac Surg. 2020 Jan;109(1):249-254. doi: 10.1016/j.athoracsur.2019.07.083. Epub 2019 Sep 12.

Abstract

BACKGROUND

We reviewed the efficacy of intraoperative intercostal nerve cryoanalgesia for pain control in patients undergoing descending and thoracoabdominal aortic aneurysm repairs.

METHODS

During 2013 and 2017, 241 patients underwent descending and thoracoabdominal aortic aneurysm repair. Of those, 38 patients were treated with intraoperative cryoanalgesia to the intercostal nerves at the level of 4th to 10th under electromyography guidance and were compared with patients who did not receive cryoanalgesia. Both groups received multilevel paravertebral block and local infiltration with liposomal bupivacaine. Numerical pain scale scores and amount of opioid usage in morphine milligram equivalences on the first to fourth and eighth postoperative days were collected. We excluded patients from the study who were extubated after the third postoperative day or who were reintubated.

RESULTS

One hundred twenty-six patients met the inclusion criteria: 28 in the cryoanalgesia group and 98 in the control group. Preoperative patient demographics were similar in both groups, except for more frequent chronic dissection in patients with cryoanalgesia (93% vs 65%, P = .004). Postoperative major complications, length of stay, and discharge to home were not significantly different in either group. However, median ventilation hours were significantly shorter in the cryoanalgesia group (5 vs 12 hours, P < .001). Opioid use was significantly less in the cryoanalgesia group after postoperative day 4. Indexed morphine milligram equivalences, adjusted with body surface area, and numerical pain scale scores were significantly lower in the cryoanalgesia group throughout the postoperative course.

CONCLUSIONS

Intercostal nerve cryoanalgesia under electromyography guidance provided improved pain control and reduced narcotic use after descending and thoracoabdominal aortic aneurysm repairs compared with those who only received paravertebral block.

摘要

背景

我们回顾了肋间神经冷冻镇痛在接受降主动脉和胸腹主动脉瘤修复术患者中的疗效。

方法

在 2013 年至 2017 年间,有 241 例患者接受了降主动脉和胸腹主动脉瘤修复术。其中 38 例患者在肌电图引导下接受肋间神经冷冻镇痛治疗,第 4 至 10 肋,与未接受冷冻镇痛的患者进行比较。两组均接受多节段椎旁阻滞和局部注射包载布比卡因的脂质体。收集术后第 1 至 4 天和第 8 天的数字疼痛评分和吗啡毫克等效物的阿片类药物用量。我们排除了术后第 3 天拔管或再次插管的患者。

结果

126 例患者符合纳入标准:冷冻镇痛组 28 例,对照组 98 例。两组患者术前人口统计学特征相似,但冷冻镇痛组慢性夹层更常见(93% vs 65%,P=0.004)。两组术后主要并发症、住院时间和出院回家情况无显著差异。然而,冷冻镇痛组通气时间中位数明显缩短(5 小时 vs 12 小时,P<0.001)。术后第 4 天,冷冻镇痛组阿片类药物用量明显减少。调整体表面积后,冷冻镇痛组的吗啡毫克等效物指数和数字疼痛评分在整个术后过程中均显著降低。

结论

与仅接受椎旁阻滞的患者相比,肌电图引导下肋间神经冷冻镇痛可提供更好的疼痛控制,并减少降主动脉和胸腹主动脉瘤修复术后的阿片类药物使用。

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