The Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Str., 620014 Ekaterinburg, Russia.
The Institute of Natural Sciences, the Ural Federal University, 620000 Ekaterinburg, Russia.
Int J Mol Sci. 2020 Jan 21;21(3):690. doi: 10.3390/ijms21030690.
Outbred female rats were exposed to inhalation of lead oxide nanoparticle aerosol produced right then and there at a concentration of 1.30 ± 0.10 mg/m during 5 days for 4 h a day in a nose-only setup. A control group of rats were sham-exposed in parallel under similar conditions. Even this short-time exposure of a relatively low level was associated with nanoparticles retention demonstrable by transmission electron microscopy in the lungs and the olfactory brain. Some impairments were found in the organism's status in the exposed group, some of which might be considered lead-specific toxicological outcomes (in particular, increase in reticulocytes proportion, in δ-aminolevulinic acid (δ-ALA) urine excretion, and the arterial hypertension's development).
杂种雌性大鼠在鼻腔暴露装置中每天暴露于 1.30 ± 0.10 mg/m 的浓度下 4 小时，连续 5 天吸入现场产生的氧化铅纳米颗粒气溶胶。一组大鼠在类似条件下进行假暴露作为对照。即使是这种相对低水平的短时间暴露也与通过透射电子显微镜在肺部和嗅脑中可观察到的纳米颗粒的保留有关。在暴露组中发现了一些机体状态的损伤，其中一些可能被认为是特定于铅的毒理学结果（特别是网织红细胞比例增加、δ-氨基酮戊酸（δ-ALA）尿排泄增加和动脉高血压的发展）。
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