含铅和镉纳米颗粒的比较性及联合血管毒性

Bushueva Tatiana V, Minigalieva Ilzira A, Panov Vladimir G, Sutunkova Marina P, Gurvich Vladimir B, Shur Vladimir Ya, Shishkina Ekaterina V, Naumova Anna S, Artemenko Elizaveta P, Katsnelson Boris A

The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Yekaterinburg, Russia.

Institute of Industrial Ecology, the Urals Branch of the Russian Academy of Sciences, Ekaterinburg, Russia.

Dose Response. 2021 Feb 11;19(1):1559325820982163. doi: 10.1177/1559325820982163. eCollection 2021 Jan-Mar.

toxicological experiments were performed on an endothelial cell line exposed to different doses of spherical nanoparticles of cadmium and/or of lead sulfides with mean diameter 37 ± 5 nm and 24 ± 4 nm, respectively. Toxic effects were estimated by Luminescent Cell Viability Assay, endothelin-1 concentration and cell size determination. Some dose-response relationships were typically monotonic (well approximated with hyperbolic function) while others were bi- or even 3-phasic and could be described within the expanded hormesis paradigm. The combined toxicity type variated depending on the effect it was assessed by.

对一种内皮细胞系进行了毒理学实验，该细胞系暴露于不同剂量的镉球形纳米颗粒和/或硫化铅球形纳米颗粒，其平均直径分别为37±5纳米和24±4纳米。通过发光细胞活力测定、内皮素-1浓度和细胞大小测定来评估毒性作用。一些剂量反应关系通常是单调的（用双曲线函数能很好地近似），而其他的则是双相甚至三相的，并且可以在扩展的兴奋效应范式内进行描述。联合毒性类型根据所评估的效应而变化。