Division of General and Hepatobiliary Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy.
Division of Minimally Invasive, General and Robotic Surgery, University of Illinois at Chicago, Chicago, US.
Sci Rep. 2020 Jan 23;10(1):1072. doi: 10.1038/s41598-020-57721-4.
Increasing evidence advocates the prognostic role of RDW in various tumours. We analysed 591 patients to assess whether RDW is a prognostic factor for overall (OS) and cancer-related survival (CRS) for patients with colorectal cancer (CRC). The data were retrieved from a retrospective database. The optimal cut-off value for RDW was set at 14.1%; accordingly, two groups were considered: those with a value equal or lower than 14.1% (L-RDW), and those with a value higher than 14.1% (H-RDW). The mean value of RDW rose from pT1 to pT4 tumours. H-RDW correlated with age above the mean, colonic location of the lesion, pT and TNM stage. Finally, H-RDW was significantly associated with the intent of surgery: almost 50% of patients who underwent a non-curative resection presented H-RDW, compared to 19.3% in R0 resections. OS was significantly lower in patients with H-RDW. CRS was similar in the two groups. Stratifying patients according to TNM stage worse OS was associated with H-RDW only in early stages, whereas there was no difference for stages II-IV. Multivariate analysis confirmed that H-RDW was not an independent prognostic factor. Although H-RDW correlated with some negative clinical-pathological factors, it did not seem to independently influence OS and CRS.
越来越多的证据表明，RDW 在各种肿瘤中具有预后作用。我们分析了 591 例患者，以评估 RDW 是否是结直肠癌（CRC）患者总生存期（OS）和癌症相关生存期（CRS）的预后因素。这些数据来自回顾性数据库。将 RDW 的最佳截断值设定为 14.1%；因此，将患者分为两组：RDW 值等于或低于 14.1%（L-RDW）的组，以及 RDW 值高于 14.1%（H-RDW）的组。RDW 的平均值从 pT1 肿瘤升高到 pT4 肿瘤。H-RDW 与平均年龄以上、病变的结肠位置、pT 和 TNM 分期相关。最后，H-RDW 与手术意图显著相关：接受非治愈性切除术的患者中，近 50%的患者出现 H-RDW，而 RO 切除术中的患者为 19.3%。H-RDW 患者的 OS 明显降低。两组的 CRS 相似。根据 TNM 分期分层，H-RDW 与 OS 较差相关仅在早期阶段，而在 II-IV 期则没有差异。多变量分析证实，H-RDW 不是独立的预后因素。尽管 H-RDW 与一些负面的临床病理因素相关，但它似乎并没有独立影响 OS 和 CRS。
