Department of Clinical Laboratory, Shanghai Tongji Hospital, Tongji University School of Medicine, 200065 Shanghai, China.
Sol Sherry Thrombosis Research Center, Temple University, 19140 Philadelphia, PA, USA.
Clin Chim Acta. 2018 Apr;479:98-102. doi: 10.1016/j.cca.2018.01.022. Epub 2018 Feb 2.
Red blood cell distribution width (RDW) is a parameter of standard full blood count tests that reflects the size variability of erythrocytes In recent studies, RDW levels have been associated with ischemic heart disease, acute and chronic heart failure, hypertension, and inflammatory bowel disease. However, it is unclear whether RDW is associated with colorectal cancer.
Eighty-five patients were diagnosed with colorectal cancer. Fifty-four other patients each diagnosed with colon polyps during the same period served as the control group. The patients were classified according to the seventh edition of the AJCC Cancer Staging Manual of 2009 into groups of different cancer stages, and simultaneously divided into groups with or without metastasis. The multigroup metering data was tested by a non-parametric Kruskal-Wallis H test, and the two subsets of patients formed above were compared using a Mann-Whitney U test. The association between continuous variables was assessed by Spearman correlation analysis while the association between RDW and colorectal cancer metastasis was estimated by receiver operating characteristic (ROC) curve analysis.
Increased RDW was observed in patients with colorectal cancer. The RDW was significantly different for each subgroup of colorectal cancer as follows: stage III + IV > stage III, T3 + T4 > T1 + T2, N1 + N2 > N0, and M1 > M0 (P < 0.05). The area under the receiver-operating characteristic curve of the RDW in the diagnosis of colorectal cancer metastasis was 0.721 (95% confidence interval of 0.612-0.831).
The value of RDW is closely related to colorectal cancer metastasis.
红细胞分布宽度（RDW）是标准全血计数测试的一个参数，反映了红细胞的大小变异性。最近的研究表明，RDW 水平与缺血性心脏病、急性和慢性心力衰竭、高血压和炎症性肠病有关。然而，RDW 是否与结直肠癌有关尚不清楚。
85 例患者被诊断为结直肠癌。同期另外 54 例被诊断为结肠息肉的患者作为对照组。根据 2009 年 AJCC 癌症分期手册第七版，患者被分为不同癌症分期的组，并同时分为有或无转移的组。多组计量数据采用非参数 Kruskal-Wallis H 检验进行检验，上述两组患者采用 Mann-Whitney U 检验进行比较。连续变量之间的关系采用 Spearman 相关分析进行评估，而 RDW 与结直肠癌转移之间的关系采用接收者操作特征（ROC）曲线分析进行估计。
结直肠癌患者的 RDW 升高。RDW 在结直肠癌的每个亚组中均有显著差异：III+IV 期>III 期，T3+T4>T1+T2，N1+N2>N0，M1>M0（P<0.05）。RDW 对结直肠癌转移的诊断的 ROC 曲线下面积为 0.721（95%置信区间为 0.612-0.831）。
RDW 值与结直肠癌转移密切相关。
